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Tadalafil Side Effects: Common, Mild, and Serious

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Did you know that Tadalafil is one of the most effective and fastest-working medicines for Erectile Dysfunction(ED)?

Your doctor may prescribe you Tadalafil or Cialis if you have persistent trouble having or holding an erection.

Cialis is a brand name for Tadalafil.

Though effective, taking Tadalafil can result in adverse effects sometimes. It is essential to talk to your healthcare provider before taking the medication to minimize the risk of Tadalafil side effects.

This article will discuss the common, mild, and severe side effects of Tadalafil.

Common side effects of Tadalafil

side effect of tadlafilSource: pixelshot
Sick man

Some of the most common Tadalafil side effects, as per FDA data, including

These side effects are usually more prevalent than others after taking Tadalafil. Yet they may not be a reason for concern as they go away on their own in most cases.

You may need to see a doctor if these symptoms persist for a long time or start to bother you.

Mild Tadalafil side effects

Taking Tadalafil can cause several mild side effects. These side effects are not serious and do not cause extreme discomfort.

You may not need medical help as they go away on their own in some time. Usually, a person may feel relief from these effects as the medicine leaves the body.

But call a doctor if they become serious or last for a long time.

Mild side effects of Tadalafil are

  • headache
  • upset stomach and indigestion
  • back pain
  • muscle pain
  • stuffy nose or runny nose
  • flushing
  • pain in your arms or legs
  • upper respiratory infection
  • cough
  • diarrhea
  • urinary tract infection
  • heartburn
  • abdominal (belly) pain

You should note that this list does not contain all the possible mild side effects of Tadalafil.

As per FDA prescribing information, most of these adverse reactions may result from once daily use of Cialis (Tadalafil).

Did you know that lower doses of Tadalafil can be taken daily, which sets it apart from other ED pills like Sildenafil? For an in-depth comparison between the two, delve into this articleTadalafil vs Sildenafil: What’s the Difference?

Severe side effects of Tadalafil

Taking Tadalafil can lead to the development of more severe side effects sometimes. 

Serious side effects may include hearing or vision problems. It may also cause Priapism in rare cases which is a medical emergency.

These side effects can be life-threatening sometimes. Call your doctor immediately if you develop serious side effects of Tadalafil. 

Here is a list of possible severe Tadalafil side effects.

  • Priapism: It is a painful erection lasting for 4 hours or more, which may be painful sometimes.
    An study suggests that using PDE-5 inhibitors such as Tadalafil (Cialis) may induce Priapism.
  • Hearing problems: You may notice changes in your hearing abilities after taking Tadalafil. Symptoms may include ringing in the ears, difficulty hearing, or sudden deafness.
    As per reports, sudden sensorineural hearing loss may be associated with using Tadalafil.
  • Vision problems: Tadalafil may cause temporary vision changes, such as increased sensitivity to light or blurred vision. Serious eye problems may include sudden vision loss in rare cases.
    According to studies, NAION and permanent vision loss after ingestion of PDE-5 inhibitors such as Tadalafil have been reported.

Other serious side effects from Tadalafil may include blood pressure changes. The medicine can cause extremely low blood pressure, which may cause you to faint or have a stroke or heart attack.

This is not an exhaustive list of Tadalafil’s side effects. Consult a doctor before taking Tadalafil or if you face any problems.

Not sure of which doctor to consult for ED concerns? This article has all the guidance– “Erectile Dysfunction Doctors: Know the Top 3 Experts“.

NAION (Non-Arteritic Anterior Ischemic Optic Neuropathy) is the loss of blood flow to the optic nerve, which may cause sudden vision loss.

How to avoid Tadalafil side effects

avoid tadlafil side effectsSource: towfiqu_ahamed_barbhuiya
Health issue

Most side effects of Tadalafil go away on their own, and you may not need to take any actions to get rid of them.

But some adverse effects may be a little more serious and may need medical help or home remedy.

You may need to consult a doctor for persistent headaches or medical emergencies like a heart attack or stroke.

But prevention is always better than cure!

Here are some suggestions to help you avoid side effects after taking Tadalafil.

  • Inform your doctor about your prevailing health conditions and the medicines you take to avoid possible drug or disease interaction.
  • Avoid alcohol or grapefruit juice as they can affect the working of the medicine. Alcohol use can enhance the risk of certain side effects.
  • Do not take more than one Tadalafil dosage in a day or as your doctor prescribes.
People with heart or blood pressure problems should consult a doctor before taking the medicine to avoid the risk of a heart attack or stroke.

The bottom line

Tadalafil is one of the most used medications for ED treatment. Though effective, taking Tadalafil can result in side effects sometimes.

You may face common side effects such as headaches, flushing, or Nausea, which mostly go away on their own within an hour.

Most side effects, such as back or muscle pain, may be relieved as the medicine leaves the body.

Taking Tadalafil can lead to serious side effects in rare cases. Severe side effects may include hearing issues or permanent vision changes.

Seek immediate medical help if you develop serious side effects or have a medical emergency.

But as previously mentioned, ‘prevention is better than cure!’.

Consult a doctor before taking the medicine to avoid potential Tadalafil side effects. 

Your doctor may suggest Tadalafil because the benefit of the medicine may be more than the risk of side effects.

Frequently Asked Questions

Does Tadalafil increase size?

Tadalafil cannot increase the size of your penis. In fact no ED pill can do so.
There is insufficient research to suggest that Tadalafil can increase the size of the penis.

Can Tadalafil damage your heart?

Tadalafil can result in serious side effects in people with underlying heart conditions.
Tadalafil can help you have or maintain an erection long enough for sex. Having sex can put extra strain on the heart, especially on those with heart disease.

Who should not take Tadalafil?

People with heart, liver, or blood pressure problems should consult a doctor before taking Tadalafil. 
Tadalafil is not meant for use by females, especially pregnant females.

Can Tadalafil damage kidneys?

Taking Tadalafil is generally safe for use in people with kidney problems. But it is important to consult a medical professional before taking the medicine.
There is insufficient research to suggest that Tadalafil can damage the kidneys.

Is long-term use of Tadalafil harmful?

Tadalafil is generally safe for use in most males. A clinical study shows that using Tadalafil once daily for 18 to 24 months is safe and well tolerated.

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Photo of author Janet Fudge
Janet Fudge is a highly skilled and experienced pharmacologist who serves as a contributing writer for With a strong academic background from a premier US University and a passion for helping others, Janet has become a trusted voice in the pharmaceutical world. After completing her Doctor of Pharmacy degree, Janet embarked on a successful career in the pharmaceutical industry, working with various clients, including hospitals, retail pharmacies, and drug manufacturers. Her in-depth knowledge of pharmacology and dedication to patient-centered care has led her to excel in her field. As a writer for, Janet uses her wealth of expertise to provide readers with accurate, reliable, and up-to-date information on various topics related to medicine and healthcare. Her engaging writing style and ability to break down complex topics into easily digestible content make her a valuable resource for healthcare professionals and the general public.
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