Among the many Erectile Dysfunction (ED) treatments available, one of the most debated comparisons is Stendra vs Cialis. Both are FDA-approved Phosphodiesterase type 5 (PDE5) inhibitors devised to increase blood flow to the penis during sexual stimulation. However, the similarities end there—each ED medication has unique strengths.
Stendra, containing Avanafil, is the newer of the two, known for its rapid onset of action, making it a convenient option for men seeking more flexibility and less planning. Cialis with Tadalafil, on the other hand, is recognized for its longer-lasting effects and the added benefit of once-daily dosing, offering greater spontaneity for some users.
This article offers a side-by-side breakdown of these two treatments to help you compare cost, duration, dosage, and side effects. Read on to know which one best fits your lifestyle and needs.
Overview of Stendra vs Cialis
Both Stendra and Cialis are PDE5 inhibitors effective for treating ED, but they differ in cost, dosage, onset, and food interaction.
Here is a quick side-by-side comparison:
| Feature | Stendra | Cialis |
| Active ingredient | Avanafil | Tadalafil |
| Mechanism of action | PDE5 inhibitor increases blood flow during arousal | PDE5 inhibitor increases blood flow during arousal |
| Effectiveness | High success rate across ED severities | Effective in 70–80% of users; also treats BPH |
| Onset of action | Rapid onset | Slower onset |
| Duration of action | Shorter duration | Extended duration |
| Dosage options | 50mg, 100mg, 200mg | 2.5mg, 5mg, 10mg, 20mg |
| Daily use option | No | Yes |
| Side effects | Headache, nasal congestion, flushing, and back pain | Headache, muscle pain, indigestion, flushing |
| Cost range | Higher (brand-only or newer generic) | Lower (especially generic Tadalafil) |
| Generic availability | Limited | Widely available |
| Food interaction | Less affected by food | May be delayed by high-fat meals |
| Drug interactions | Avoid with nitrates, alpha-blockers, CYP3A4 inhibitors | Avoid with nitrates, alpha-blockers, CYP3A4 inhibitors |
| Lifestyle fit | Best for occasional, planned use | Great for daily use and spontaneity |
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Active ingredients, mechanism of action, and effectiveness
Stendra contains Avanafil, while Cialis is formulated with Tadalafil. Both Stendra and Cialis work by blocking the PDE5 enzyme, making it easier to achieve and maintain an erection.
Here’s how each medication compares in terms of effectiveness:
- Stendra (Avanafil): Known for fast action and fewer off-target effects. It starts working in as little as 15 minutes and has shown strong success rates across multiple age groups and ED severity levels.
- Cialis (Tadalafil): It is effective in 60-90% of men. It offers the added benefit of treating Benign Prostatic Hyperplasia (BPH) and can be used daily. It takes effect in 30-60 minutes but lasts up to 36 hours.
When comparing Stendra vs Cialis reviews, both show high satisfaction, but Stendra often wins on quick action, while Cialis is favored for flexibility.
Onset and duration
When comparing Erectile Dysfunction treatments, Stendra’s duration of action vs Cialis is a key consideration. How quickly each medication starts working and how long the effects last can significantly influence which option best suits your needs.
- Stendra: It begins working within 15–30 minutes, peaks at around 20–40 minutes, and maintains effectiveness for about 6–12 hours, making it ideal for those who prefer flexibility and spontaneity in timing.
- Cialis: It begins working within 30 to 60 minutes, reaches peak effectiveness in about 1 to 2 hours, and may remain active for up to 36 hours—often referred to as “the weekend pill” due to its long-lasting results.
Stendra is preferred by users who need a fast-acting solution, while Cialis is better for those who desire a longer window of opportunity without the pressure of precise timing.
Dosage comparison
The prescribed dosages for Stendra dosage vs Cialis vary based on usage type and patient response.
- Stendra: Available in 50mg, 100mg, and 200mg. The typical starting dose is 100mg, taken 15–30 minutes before sex. The maximum dose is a single dose per 24 hours.
- Cialis: Comes in 2.5mg, 5mg, 10mg, and 20mg. Lower doses (2.5mg or 5mg) are used daily, while higher doses (10mg, 20mg) are taken as needed.
Both medications offer dosing flexibility, but Cialis gives the option of once-daily treatment, which some users find more convenient.
Side effects comparison
Both medications are generally well-tolerated but come with possible side effects.
Stendra side effects include the following:
- Headache
- Nasal congestion
- Back pain
- Facial flushing
Some Cialis side effects include:
- Headache
- Indigestion
- Muscle aches
- Flushing
- Pain in limbs
Severe but rare side effects of both medications include vision or hearing loss and Priapism (prolonged erection). Stendra’s targeted action may lead to fewer side effects for some people.
Cost comparison
Cost can play a big role in choosing the proper Erectile Dysfunction medication. Cialis is often the more economical choice regarding generic availability and approved lower-cost options.
For example, current pricing data (without insurance) shows that for a 30-tablet pack:
- Stendra: Stendra (50 mg) costs around $68.31 per unit, totaling roughly $2,049.19 for a similar 30-tablet pack.
- Cialis: Cialis (20 mg) costs approximately $59.09 per unit, costing about $1,772.63.
Cialis (especially generic Tadalafil) is more budget-friendly if affordability is a concern. Always check insurance coverage and discounts.
Generic Stendra or Avanafil is challenging to find in the US. However, you can order them easily from the Cheap Medicine Shop.
Food interactions
The timing and type of meals you consume can influence how effectively ED medications work.
- Stendra: Typically maintains its rapid onset even when taken with moderate meals, offering more flexibility around food.
- Cialis: May experience delayed absorption if taken with a high-fat meal, although it remains effective.
For best results, take Stendra and Cialis on an empty stomach when possible.
Drug interactions
Stendra and Cialis can interact with other medications, leading to potential health risks. However, subtle differences in their interaction profiles may influence your treatment decision.
- Nitrates: Never take Stendra or Cialis with nitrate medications (used for chest pain). This can cause a sudden, dangerous drop in blood pressure.
- Alpha-blockers: These medications for High Blood Pressure or prostate issues may cause added hypotensive effects when combined with ED medications. Close monitoring is required.
- Blood pressure medications: Stendra and Cialis can amplify the effects of antihypertensives, increasing the risk of dizziness and fainting.
- CYP3A4 inhibitors: Medications such as certain antibiotics, antifungals, and HIV medications can raise blood levels of these ED medications, leading to more side effects.
It is crucial to inform your healthcare provider about all current medications and supplements to ensure safe use and prevent drug interactions.
Lifestyle fit and convenience
Lifestyle fit and convenience play a significant role in choosing between Stendra vs Cialis.
- Stendra: Offers more flexibility for men who want quick results without extensive planning. Its short duration makes it suitable for occasional, planned encounters.
- Cialis: Better suited for men who prefer spontaneity and a longer window of effectiveness. The daily dosing option eliminates the need to take medication before sexual activity.
These differences can significantly affect your selection of the medication that best suits your lifestyle and comfort level.
Conclusion
Both Stendra and Cialis are effective treatments for Erectile Dysfunction, but each has its strengths. Stendra works fast and may cause fewer side effects, making it suitable for planned encounters. Cialis provides extended coverage and flexibility in dosing and is cost-effective when taken as a generic.
If you prioritize spontaneity and long-lasting effects, Cialis may be a better option. But if you are looking for a quicker onset and more predictable results for occasional use, Stendra could be ideal.
Your choice between Stendra vs Cialis depends on your lifestyle, timing needs, and sensitivity to side effects. Always consult your healthcare professional or expert to determine the most appropriate ED medication for your needs.
Frequently Asked Questions
Is Stendra stronger than Cialis?
Not necessarily. Stendra acts faster, but Cialis lasts longer and offers daily use benefits. Their strength depends on personal needs like timing and treatment goals. Consult your doctor to decide which is better suited for your lifestyle and health condition.
Can Stendra or Cialis affect fertility?
No, neither Stendra nor Cialis impacts fertility or sperm quality. These medications are devised to enhance blood flow to the penis and do not influence hormone levels or sperm production.
Can I drink alcohol while taking Stendra or Cialis?
Light to moderate alcohol consumption may be tolerated, but combining these drugs with excessive alcohol increases the risk of side effects such as dizziness, fainting, or Low Blood Pressure. Always use caution and limit intake.
Who should not use Stendra and Cialis?
Stendra and Cialis are unsafe for men advised against sex due to heart risks, those with severe liver/kidney disease (dose adjustments may apply), or anyone allergic to their ingredients. Always consult a doctor before use.
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