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The Blue Pill (Sildenafil)

The Blue Pill (Sildenafil)

The Blue Pill (Sildenafil)


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The Blue Pill (Sildenafil)

Sildenafil, often known as a little blue pill is an oral therapy which is highly recommended by the doctors to treat sexual dysfunction in men. Under the brand name of Viagra, sildenafil is sold to treat sexual dysfunctions known as erectile dysfunction and pulmonary hypertension. Sildenafil or a little blue pill belongs to the class of phosphodiesterase type 5 inhibitors and it works by increasing the flow of blood to the penile region. Erectile dysfunction is one of the most common sexual dysfunctions in men. Each year, millions of men are diagnosed with this problem and many time, men fail to share their problem. Erectile dysfunction is a condition in which men’s ability to maintain an erection is affected. Men having erectile dysfunction fails to attain or maintain penile erection sufficient enough to have a satisfactory sexual intercourse.

Uses of Sildenafil

Erectile Dysfunction

Erectile Dysfunction is a condition in which men’s ability to maintain an erection is affected. Men having erectile dysfunction fails to attain or maintain penile erection sufficient enough to have satisfactory sexual intercourse. There are many factors that can cause erectile dysfunction such as stress, smoking, drinking, diabetes, and advancing age. Erectile dysfunction is a complex process and it involves multiple factors such as nerves, muscles, hormones, and emotions.

Pulmonary Hypertension

Pulmonary hypertension is a condition which occurs when there is an increase in the blood pressure that affects the arteries and makes it difficult for the heart to pump blood.

Raynaud’s Phenomenon

Raynaud’s phenomenon is a condition in which the blood vessels are affected and primarily in the fingers and toes.

Working Of Sildenafil Or A little Blue Pill

A firm erection requires a good arterial inflow of blood and an efficient reduction of venous outflow. Sildenafil or a little blue pill inhibits the phosphodiesterase type 5 enzymes and enhances the effect of nitric oxide. As a result, the degradation of cyclic guanosine monophosphate (cGMP) is stopped in the corpus cavernosum. cGMP plays an important role attaining a penile erection. Also, with a release of nitric oxide, sildenafil increases the level of cGMP in the erectile tissue which causes smooth muscle relaxation and increases the inflow of blood in the penis region.

Contradictions Associated with Sildenafil

  • Nitrates - Sildenafil or a blue pill is known to interact with nitrates as sildenafil is shown to potentiate the hypotensive effect of nitrates.
  • Hypersensitivity reactions - Patients who are sensitive to a blue pill or any ingredient of this drug are recommended to avoid the consumption of this drug.  
  • Alpha Blockers - Any interaction between the alpha blockers and sildenafil or blue pill is not recommended as it can cause a hypotensive effect on a man.
  • Antihypertensives - Sildenafil or a blue pill is known to have systemic vasodilatory properties and interactions with the hypertensive drugs can lead to the blood pressure.