When we talk about treating Erectile Dysfunction (ED), two popular medications often come into the spotlight: Vardenafil and Sildenafil. Both belong to the same class of medications, Phosphodiesterase Type 5 (PDE5) inhibitors, with similar processes for achieving and maintaining erections.
However, they are not identical twins. From small changes in how quickly they work to variances in potential side effects and suggested dosages, choosing between them is more than simply picking a brand—it’s about discovering what best matches your lifestyle and health needs.
This Vardenafil vs Sildenafil comparison helps guide you through the possibilities for a more fulfilling, intimate life.
Vardenafil vs Sildenafil: A quick comparison
Vardenafil and Sildenafil are the two most commonly prescribed ED pills with similar modes of action. Both pills enhance blood supply to the penis, leading to an erection sufficient for a satisfying sexual encounter. However, they differ in terms of dosages, cost, and side effects.
The table below highlights the key differences between the two pills, helping you make an informed choice after consulting your doctor.
| Feature | Vardenafil | Sildenafil |
| Onset of action | Within 60 minutes; sometimes, start working in 10 minutes | Within 60 minutes |
| Dosages | 2.5 mg, 5 mg, 10 mg, and 20 mg | 25 mg, 50 mg, and 100 mg |
| Starting dose | 10 mg | 50 mg |
| Side effects | No | Yes |
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Sildenafil vs Vardenafil: How quickly do they work?
Vardenafil typically starts working within 30-60 minutes. However, a randomized controlled trial published by The Journal of Sexual Medicine in 2004 suggests that it can be as fast as 10 minutes for some individuals. Its effects normally last 4-5 hours, while in some cases, they might last up to 12 hours.
On the other hand, Sildenafil has a comparable onset of action, generally within 30-60 minutes, although it might be altered by meals, potentially delaying the impact. Sildenafil’s duration of action is also around 4 hours.
While their start timings are similar, Vardenafil may have a somewhat longer window of efficacy for some men.
Dosage and administration
Vardenafil and Sildenafil are both used as needed to treat Erectile Dysfunction in men; however, their doses differ slightly. Vardenafil tablets are available in 2.5 mg, 5 mg, 10 mg, and 20 mg strengths, with a common starting dose of 10 mg administered 30 to 60 minutes before sexual activity.
On the other hand, Sildenafil dosage varies from 25 mg to 100 mg, with 50 mg serving as the most popular beginning dose. Both medications should not be taken more than once a day, and they are most effective when taken on an empty stomach since high-fat foods might cause them to take longer to take action.
Among the two, Vardenafil has been discovered to be more powerful, which means that a lesser dose is typically sufficient. Sildenafil, on the other hand, requires a more significant amount, such as 50 mg, to be effective. However, your doctor will decide the most suitable dose based on your medical needs and response to the treatment.
Which is more effective and affordable?
Vardenafil and Sildenafil are both effective treatments for ED, with success rates varying between 60% and 80%, depending on individual reaction and health status. In terms of efficacy, they are generally equivalent; nevertheless, some men might find that one works better or has fewer side effects than the other.
Sildenafil, also known as generic Viagra, is typically less expensive and more readily available than Vardenafil or generic Levitra. Vardenafil is slightly more costly, but it may last longer for some individuals. Ultimately, the decision is generally based on personal response, cost, and preference.
Are there any side effects?
Yes, Vardenafil and Sildenafil share some common side effects due to their comparable actions as PDE5 inhibitors. These may include:
- Headaches
- Nasal congestion
- Indigestion
- Dizziness
- Facial flushing (a feeling of warmth on the face and neck)
However, Sildenafil is more commonly related to visual problems such as changes in color vision or greater light sensitivity than Vardenafil. Serious but uncommon adverse effects of both ED pills include sudden visual or hearing loss, persistent and painful erections (Priapism), and cardiovascular problems.
Individual reactions to these medications might vary, so it’s essential to consult a doctor about potential side effects and any pre-existing issues before taking either Vardenafil or Sildenafil.
Conclusion
There is no straightforward answer to the question of Vardenafil vs Sildenafil. Vardenafil stands out for its possible increased selectivity and efficacy, which is frequently associated with a reduced incidence of certain side effects such as impaired color vision, making it an appealing alternative for people seeking a more tailored treatment strategy.
Sildenafil, on the other hand, is well-known for its authenticity and proven track record. While both medicines are typically well-tolerated and have comparable overall efficacy, the best option is determined by an individual’s preferences, tolerance for each medicine, and medical history.
Hence, consulting with a healthcare practitioner is essential to determining which of these medications is most suited to your specific needs.
Frequently Asked Questions
How do the side effects compare for Vardenafil and Sildenafil?
Vardenafil and Sildenafil have similar side effects, including headaches, flushing, and nasal congestion. However, Sildenafil is more likely to induce visual disturbances, while Vardenafil generally works better in men with heart problems. Individual responses might differ.
What are common drug interactions for Vardenafil and Sildenafil?
Vardenafil and Sildenafil frequently interact with nitrates (e.g., nitroglycerin), alpha-blockers, certain antifungals, HIV protease inhibitors, and some antibiotics. These combinations can lead to a severe decrease in blood pressure or raise the risk of adverse reactions.
Can Vardenafil and Sildenafil be taken together?
No, Vardenafil and Sildenafil should not be used together. Both are PDE5 inhibitors used for ED treatment, and using them together raises the risk of significant side effects, including Low Blood Pressure, dizziness, and heart problems.
Which is better for men with Diabetes-related ED?
Both are effective for Diabetes-related ED; however, Vardenafil may have a minor advantage in men with Diabetes, showing stronger improvements in erection quality in some clinical studies. Individual responses may vary; hence, consulting a doctor is essential before beginning the treatment.
Can either be taken daily, similar to low-dose Cialis?
No. Vardenafil and Sildenafil are only intended to be used as needed. Daily usage is not suggested due to shorter half-lives and the possibility of increasing side effects. Cialis is the only PDE5 inhibitor licensed for everyday usage.
Why was Vardenafil ceased?
Vardenafil was withdrawn in multiple markets because of decreasing sales and market competition, not for safety reasons. Generic versions are still accessible, and the medicine is still authorized for treating Erectile Dysfunction.
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