Vardenafil Vs Sildenafil: Which One to Buy?

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Written by- Janet Fudge, Pharma-D

Vardenafil and Sildenafil are both medications.

They are known to treat Erectile Dysfunction (ED) in men or Assigned Males at Birth (AMAB).

Erectile Dysfunction is an inability to attain and hold a firm erection.

Sildenafil was the first medicine that Food and Drug Administration (FDA) approved to treat ED, whereas, Vardenafil was approved afterward.

Let us get into the article to understand: Vardenafil vs Sildenafil and which is the most suited medicine for you.

Sildenafil and Vardenafil basics

Sildenafil, as mentioned, is the first FDA-approved medication in 1998 for impotence or Erectile Dysfunction.

The active ingredient in Viagra and generic Viagra medications is Sildenafil.

On the other hand, FDA approved Vardenafil in 2003, and it came into the market under the brand name Levitra.

Other generic variants of Vardenafil include Vilitra, Filitra, and Snovitra.

Sildenafil is also used in treating Pulmonary Arterial Hypertension. Whereas, Vardenafil is only used as an Erectile Dysfunction medication.

Vardenafil vs Sildenafil: How do they work

Vardenafil and Sildenafil work in the same way. 

They both belong to the group of Phosphodiesterase type 5 (PDE5) inhibitors.

PDE5 inhibition raises the levels of cyclic Guanosine Monophosphate (cGMP).

The raised cGMP levels help relax the smooth muscles. It also dilates the blood vessels in the penile region.

The dilation of blood vessels aids to increase blood circulation in the penile area.

This increased blood circulation will help a man or AMAB to get a strong erection.

However, sexual stimulation is essential to achieve an erection.

Whose effects last longer: Vardenafil or Sildenafil

The effects of Sildenafil and Vardenafil depend on the health of an individual.

The typical half-life of Vardenafil is 4-6 hours. According to an article, in some individuals, the effects of Vardenafil can also last up to 8 hours.

Whereas, Sildenafil’s half-life is 3 to 5 hours.

Meaning that the effects will start to wear off within 3 hours of consuming a Sildenafil pill.

Although the difference is not huge, Vardenafil lasts a little bit longer than Sildenafil.

Which pill works faster: Vardenafil vs Sildenafil

Person holding pillsSource: Diy13
Person holding pills

The onset of action for both Sildenafil and Vardenafil is the same.

Both medicines start to work within 30 minutes of consumption.

However, an individual’s health and other factors also play a role in how fast the medicine will work.

Moreover, there are certain foods to avoid when taking Viagra (Sildenafil) or Levitra (Vardenafil). 

This is because if you had a high-fat meal before consuming Sildenafil or Vardenafil, then the onset of action might take longer.

Vardenafil and Sildenafil absorption can be delayed due to a meal heavy in fat.

Therefore, it is advisable to take these medicines 30 to 60 minutes before intercourse.

To get better results, take Sildenafil or Vardenafil on an empty stomach or after a light meal.

Which has more side effects: Vardenafil or Sildenafil

Vardenafil and Sildenafil side effects are common.

Some of the common side effects are:

Side effects like headaches and indigestion can persist after the medicine wear off.

A painful erection lasting more than four hours is known as Priapism.
Consult your healthcare provider immediately in case of Priapism or an allergic reaction.

Sildenafil vs Vardenafil: A comparison

Vardenafil and Sildenafil are pretty similar but also have some key differences.

Let’s look at the table to understand what makes Sildenafil different from Vardenafil:

GroupPDE5 inhibitorsPDE5 inhibitors
Used in the Treatment ofErectile DysfunctionErectile Dysfunction and Pulmonary Arterial Hypertension
Brand name medicineLevitraViagra
Availability of genericsAvailableAvailable
Onset of action30 minutes30 minutes
How long do the effects lastEffects start to wear off around 4 hours but can stay up to 8 hoursIt typically last up to 3 to 5 hours

Which is more effective, Sildenafil or Vardenafil

Sildenafil and Vardenafil work the same medically.

In a study, 92% of people showed improvement in their erections after consuming Vardenafil.

Another study on Sildenafil Citrate showed 95% of men had improved erections.

Therefore, both Vardenafil and Sildenafil are equally effective in treating Erectile Dysfunction in men.

They both increase the blood flow to the penile region, which in turn helps an individual to get an erection.

The onset of action for both medicines is 30 minutes.

Which is better, Vardenafil vs Sildenafil

Sildenafil and Vardenafil are both known to be effective Erectile Dysfunction treatments

Vardenafil lasts longer than Sildenafil.

However, both medicine works within 30 minutes and causes the same side effects.

Generics of both medicines are available, which are cheaper than the brand name medicine.

Therefore, Vardenafil has a little advantage over here.

Nevertheless, before choosing any ED pill, consult your doctor first.

Quick Checkout:
Enjoy the long-lasting intimacy with Vardenafil!

Explore various generic options of Vardenafil at Cheap Medicine Shop.

Frequently Asked Questions

Does Vardenafil last longer than Sildenafil?

Yes, typically, the effects of Vardenafil last between 4 to 6 hours. Whereas, Sildenafil’s effects last up to 3 to 5 hours.

How long does it take for Vardenafil to work?

Vardenafil takes at least 30 minutes to absorb and show its effects.
However, it also depends on an individual’s health and other factors. Therefore, it is advisable to consume this medicine 30 to 60 minutes before sexual activity.

How long does it take for Sildenafil to work?

Sildenafil typically starts working within 30 minutes. However, according to factors like the consumption of high-fat meals and an individual’s health, it can take up to 1 hour.

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Photo of author Janet Fudge
Janet Fudge is a highly skilled and experienced pharmacologist who serves as a contributing writer for With a strong academic background from a premier US University and a passion for helping others, Janet has become a trusted voice in the pharmaceutical world. After completing her Doctor of Pharmacy degree, Janet embarked on a successful career in the pharmaceutical industry, working with various clients, including hospitals, retail pharmacies, and drug manufacturers. Her in-depth knowledge of pharmacology and dedication to patient-centered care has led her to excel in her field. As a writer for, Janet uses her wealth of expertise to provide readers with accurate, reliable, and up-to-date information on various topics related to medicine and healthcare. Her engaging writing style and ability to break down complex topics into easily digestible content make her a valuable resource for healthcare professionals and the general public.
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