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All You Need To Know About PDE5 Inhibitors

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Phosphodiesterase 5 inhibitors( PDE5 inhibitors) are the drugs that are widely used to block the degradation of cGMP (Cyclic guanosine monophosphate) in the smooth muscle cells lining the blood vessels supplying the central erectile tissues of the penis. 

PDE5 5 inhibitors cause relaxation of smooth muscles and maintain healthy penile function. Therefore, recommendations of PDE5 inhibitor drugs like-Sildenafil, Tadalafil( Vitalitey 50 Mg), and Vardenafil Levitra are for treating erectile dysfunction (ED). They also treat several other men’s sexual problems like premature ejaculation

Due to the high degree of effectiveness and its record, PDE5 inhibitors are the drugs of choice for treating and managing erectile function. 

Where is PDE5 Located?

Many types of PDE5 enzymes function to degrade cGMP. These PDE5 enzymes spread widely throughout the body and perform an activity in different tissues. 

For example, PDE 5 enzymes are present in the smooth muscle of the corpus cavernosum, skeletal muscle, cerebellar and pancreatic tissues, vascular and visceral smooth muscle, platelets, kidneys, and lungs. 

Can PDE5 Inhibitors Cure ED?

a dejected couple lying on bed.

 PDE5 inhibitor drugs cause vasodilation in the penis region and block the breakdown of cGMP and result in the prolonged action of the mediators of vasodilators such as nitric oxide. Penile erection is dependent on the release of nitric oxide, which stimulates the production of cGMP. 

Penile erection is a process that is occurs by the relaxation of smooth muscles in the corpus cavernosum, which is the primary erectile tissue. At sexual stimulation, nitric oxide is releases from the nerve ending in the corpus cavernosum.

It increases cGMP synthesis in the corpus cavernosum and triggers smooth muscle relaxation. This further increases the blood flow into the penis region and results in an erection. However, the erection caused is not a long-term measure. The effect goes away within a few hours.

When Should I Take PDE5?

Drugs that belong to PDE5 inhibitors treat three men’s health problems: erectile dysfunction, pulmonary arterial hypertension, and benign prostatic hyperplasia. 

Erectile dysfunction is one of the most common sexual problems in men. It is a condition in which men are incapable of attaining or maintaining a penile erection sufficient to have satisfactory sexual intercourse. Erectile function involves various factors, and problems can lead to impaired erectile function. 

Pulmonary arterial hypertension refers to the high blood pressure in the arteries going to the lungs. When the pulmonary arterial pressure exceeds 25 mm Hg, it is a sign of pulmonary arterial hypertension. 

Benign prostatic hyperplasia is a common problem among men by 50. It is a condition in which the rapid increase of the prostatic stromal cells results in an enlarged prostate gland.

What is the Best PDE5 inhibitor?


Viagra is the marketed brand name of Sildenafil. After clinical trials, one notes that the oral dose of Sildenafil expects an onset of action in 30 minutes and the estimated maximum effect at one hour. 

However, the serum half-life of this drug is four hours. Also, this drug is a lipophilic molecule, and taking a dose of this drug close to the consumption of a fatty meal reduces the efficacy of Sildenafil.

You can find other alternatives to Viagra here, such as Cenforce 100mg


Tadalafil sells in the market under the labels name Cialis and Adcirca. Cialis is a marketed pill and one of the best treatment options for erectile dysfunction and benign prostatic hyperplasia. Adcirca is a marketed pill to treat pulmonary arterial hypertension. 

Tadalafil has shown to have an onset of action as early as 16 minutes. Also, taking the dose of this drug close to the consumption of fatty meals does not affect the efficacy of Tadalafil. 


Vardenafil is present in the market under the names Levitra, Staxyn, and Vivanza. It is one of the recommended drugs to treat erectile dysfunction. 

Vardenafil is taken thirty minutes to one hour before the sexual intercourse. Also, professionals recommend consuming this drug one to two hours before having a meal or one to two hours after dinner as it can affect its efficiency. The duration and the effect of this drug remain for 5 – 7 hours. 

Frequently Asked Questions

Is caffeine a PDE5 inhibitor?

Phosphodiesterase-5 (PDE5) inhibitors treat diabetic ED by preventing the breakdown of intracellular cyclic guanosine monophosphate (cGMP). Unfortunately, caffeine, a nonselective PDE inhibitor found in our everyday diet, has a mixed reputation for erectile dysfunction.

What are the side effects of PDE5 inhibitors?

PDE5 inhibitors can cause the following adverse effects, which are generally minor:
Headaches, flushing, and stomach discomfort, as well as muscular and back pain, are symptoms that are similar to those of a typical cold.
The following are examples of uncommon side effects:
Changes in eyesight or abrupt loss of vision, which are more common in those with heart disease or diabetes; unexpected loss of hearing; prolonged or painful erections that require treatment to avoid long-term damage

What fruit is a natural Viagra?

According to one study, watermelon might be a natural Viagra. The popular summer fruit contains more citrulline, an amino acid that relaxes and dilates blood vessels like Viagra and other erectile dysfunction medications do (ED).

Is Viagra a PDE5 inhibitor?

Viagra is one of the most potent and well-known PDE5 inhibitors prescribed by doctors.

Are PDE5 inhibitors safe?

It is safe to use PDE5 inhibitors only after the doctor’s advice. However, it must be noted that if the patient is already taking medications or is suffering from a disease, the PDE5 inhibitor must be taken only after proper consultation with the doctor.

Can I buy PDE5 inhibitors over the counter?

Over-the-counter sale of PDE5 inhibitors is prohibited. It is not legal; in addition, taking the drugs without a doctor’s prescription may cause health repercussions.

What if a girl took Viagra?

The FDA has authorized Viagra for the treatment of erectile dysfunction in males. Prohibition of the drug for use in women, and trials have had inconsistent outcomes. In addition, there is no medicine “female Viagra.” Still, a few medicines have been licensed to treat sexual dysfunction in women.
A variety of factors can cause low sex desire in women. Consult your doctor before using Viagra or any other medicine. Inquire about the drugs’ possible advantages and adverse effects.

Can heart failure cause erectile dysfunction?

Erectile dysfunction, or the inability to develop and maintain an adequate hard erection for sex, might be a precursor to present or future heart issues. Similarly, receiving the appropriate medication for heart problems may assist with erectile dysfunction.
It should be noted that the consumption of these pde5 inhibitor drugs should be done only on medical advice as these drugs are known to interact with several medicines, such as nitrates. The doctor will guide you about all the related information and the medications and health conditions under which one should avoid taking these drugs. 

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Photo of author Janet Fudge
Jim Carson is a highly skilled and dedicated medical writer passionate about advancing medical practice. With years of experience in the field of medical sciences, Jim has made significant contributions to various studies aimed at improving healthcare outcomes. He currently writes for, providing expert insights and knowledge on various topics. Jim's expertise extends to various areas, including drug interactions, dosages, side effects, and best practices for medication use. In Los Angeles, Jim lives with his loving wife, children, and beloved pets. He deeply values spending time with his family and cherishes their presence. When he's not writing, Jim enjoys watching football games and staying updated with the latest sports news. Jim's writing shines through his commitment to advancing medical practice and improving healthcare outcomes. Readers can trust Jim's articles to be informative, accurate, and reliable, making him a trusted pharmaceutical information source for the website's audience.
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