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Tadalafil vs Sildenafil: What’s the Difference?

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Tadalafil and Sildenafil both treat Erectile Dysfunction (ED) in men or people Assigned Males at Birth (AMAB).

Tadalafil is better known by its brand-name Cialis, while Sildenafil is known by its brand-name version Viagra.

Erectile Dysfunction is very common in the United States. Around 30 million men in the US face erection problems.

Various Erectile Dysfunction treatments are available, and these two salts fall in the oral medications category.

Through this article, we will understand the difference between Sildenafil and Tadalafil.

We will also examine which is better Tadalafil or Sildenafil.

Which is better: Tadalafil vs Sildenafil

Deciding the better one in Tadalafil vs Sildenafil is a tough task due to their almost similar working and effects.

Both of these salts are Phosphodiesterase type 5 (PDE-5) inhibitors.

They treat erection problems by inhibiting PDE-5 enzymes in the penile region. This inhibition helps to increase the blood flow to the penis.

We will list some key differences for you to understand which Erectile Dysfunction pill is better: Sildenafil or Tadalafil.

How long do Sildenafil and Tadalafil last

Effects of Sildenafil pills last up to 4 to 5 hours, while the effects of Tadalafil pills last longer

Tadalafil pills are widely known as the ‘weekend pills’ due to their long-lasting effects. 

As per a study, their effects usually last up to 36 hours, meaning a man can take the pill on a Friday night and still enjoy using it on Sunday morning.

Which works faster: Sildenafil or Tadalafil

Tadalafil can take about 15 minutes to 2 hours to show effects. On the other hand, Sildenafil can deliver results within 30 minutes of consumption.

Heavy meals can slow Sildenafil’s absorption; however, Tadalafil is unaffected by heavy meals or alcohol.

As per MedlinePlus, take Sildenafil on an empty stomach, or before or after a light meal for best results.

Tadalafil vs Sildenafil side-effects

HeadacheSource: Rido

Sildenafil and Tadalafil side effects are common. These include:

  • Dizziness
  • Headache
  • Flushing
  • Stomach upset

A rare side-effect of these tablets may be Priapism.

If you have severe side effects, consult a doctor and seek medical help immediately.

The difference between Sildenafil and Tadalafil’s side effects is that Sildenafil may cause abnormal vision sometimes.

Both Tadalafil and Sildenafil can cause decreased vision or blindness. 

But vision changes caused by Sildenafil may also include increased sensitivity to light and difficulty in separating blue or green colors.

Another difference includes back pain or muscle pain associated with the use of Tadalafil, while Sildenafil is not known to cause such side effects.

Dosage: Tadalafil vs Sildenafil

The Food and Drug Administration (FDA) has approved four Tadalafil dosages, namely 2.5mg, 5mg, 10mg, and 20mg. 

Additionally, generic Tadalafil tablets are available up to 60mg doses.

In contrast, Sildenafil dosages are available in three options: 25mg, 50mg, and 100mg. 

But generic Sildenafil tablets are offered up to 200mg dose. 

Your doctor can decide the maximum dose you can take in a day, based on the severity of your condition and response to the treatment. 

Tadalafil vs Sildenafil: Key differences

Here’s an overview for you to understand the differences at a glance.

How fast does it work?Tadalafil can take 15 minutes to 2 hours to show effects.Sildenafil starts to show effects within 30 minutes of consumption.
How long do the effects last?The effects may last up to 36 hours.The effects last only for 4 to 5 hours.
Side effectsMuscle pain or back pain apart from other common side effects.Other than common side effects, it may cause abnormal vision.


After knowing the difference between Tadalafil and Sildenafil, you might still be confused.

This is because Tadalafil and Sildenafil work in the same way and produce similar results. 

According to a study by International Urology and Nephrology, most patients and their partners prefer Tadalafil due to the added advantage of lasting longer.

But you still need to know which ED pill to choose when it comes to Tadalafil vs Sildenafil. 

You should consult a medical professional to help you select the suitable medication for you, depending on your symptoms and diagnosis.

Consulting a doctor or medical professional is advisable due to the prevailing health conditions and the risk of potential side effects. Avoid self-medication.

  • AMAB: Assigned male at birth.
  • Erectile Dysfunction: It is the incapacity in a man to have or maintain an erection long enough to have sex.
  • PDE-5 inhibitors: They are a group of medications that affect blood flow and how cells communicate in the body. PDE-5 inhibitors block the PDE-5 enzymes to prevent them from working.
  • Priapism: It is an erection that lasts more than 4 hours. It may also result in a painful erection sometimes.
  • Frequently Asked Questions

    Does Sildenafil last longer than Tadalafil?

    No, Sildenafil does not last longer than Tadalafil. The effects of Tadalafil may last for 36 hours, while the effects of Sildenafil last for only 4 to 5 hours.

    Which is better, Sildenafil or Tadalafil?

    When it comes to Tadalafil vs Sildenafil, there is no better one as they both work the same medically. 

    Most patients prefer Tadalafil due to its long-lasting effects and lower risk of side effects. A lower risk of side effects may be associated with the fact that Tadalafil is usually consumed in lower strengths.

    However, you can consult your doctor to choose the most suitable medication, depending on your symptoms and diagnosis.

    Can I take Tadalafil daily?

    According to research, it is safe to consume Tadalafil daily. However, you should follow the instructions given by your doctor for an effective treatment.

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    Photo of author Janet Fudge
    Janet Fudge is a highly skilled and experienced pharmacologist who serves as a contributing writer for With a strong academic background from a premier US University and a passion for helping others, Janet has become a trusted voice in the pharmaceutical world. After completing her Doctor of Pharmacy degree, Janet embarked on a successful career in the pharmaceutical industry, working with various clients, including hospitals, retail pharmacies, and drug manufacturers. Her in-depth knowledge of pharmacology and dedication to patient-centered care has led her to excel in her field. As a writer for, Janet uses her wealth of expertise to provide readers with accurate, reliable, and up-to-date information on various topics related to medicine and healthcare. Her engaging writing style and ability to break down complex topics into easily digestible content make her a valuable resource for healthcare professionals and the general public.
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