US Toll Free Call/Text:
+1(888) 866-7566
Int. No Call/Text:
+1(718) 301-8411

How Long Does Tadalafil Last: Facts You Should Know

Photo of author

Tadalafil is a popular medicine to treat Erectile Dysfunction in men and Assigned Males at Birth (AMAB). 

Sometimes known as ‘the weekend pill,’ it is known for its long-lasting effects. 

But how long does Tadalafil last? 

We will discuss Tadalafil’s effectiveness, work, and similar queries in this article.

How long does Tadalafil last

tadlafil last longSource: Getty_images
Tadlafil duration in system

According to the Food and Drugs Authority, Tadalafil may last up to 36 hours.

It means Tadalafil remains in your body until 36 hours after you take it. 

Due to its long effectiveness, Tadalafil is often known as ‘the weekend pill.’

Let us discuss the working and effectiveness of Tadalafil in detail below.

How long can you last with Tadalafil

Since Tadalafil remains in your body for 36 hours after swallowing, it may produce results until that time. 

According to a study published on the NCBI site, you may last up to 36 hours after taking Tadalafil. 

It may take anywhere between 30 minutes to two hours for the medicine to show its effects.

However, the intensity of the effects may decrease with time.

How long does Tadalafil stay in your system

According to research, Tadalafil may remain in the body for up to 36 hours after you take it. 

It means Tadalafil may take 36 hours to flush out of your body completely. 

After that, Tadalafil may not be effective in showing results.

Recommended Read: What is Tadalafil Used for? Know All About Tadalafil

Until what time do the full effects of Tadalafil last

According to Healthline, Tadalafil may deliver its effects up to 36 hours. 

It means that with enough stimulation, you can get erections until that time.

A single Tadalafil pill can keep you hard for up to 36 hours.

Fun Fact
Apart from ED, Tadalafil is also useful in treating Pulmonary Arterial Hypertension and Benign Prostatic Hyperplasia.

How does Tadalafil work

tadlafil workSource: Getty_images
Effects of tadlafil

Tadalafil is a member of the class of drugs known as Phosphodiesterase type 5 (PDE5) Inhibitors.

This medicine works by blocking the action of the PDE5 enzyme in the penis.

This PDE5 enzyme reduces the amount of cGMP in the blood, which makes the penis soft.

Tadalafil opens the blood vessels in the penis by blocking PDE5.

Because of this, the penis receives a higher supply of blood.

Increased blood flow to the penile area helps you get and keep an erection.

Factors that affect Tadalafil’s effectiveness

Several factors affect how Tadalafil works. 

It can reduce the effectiveness of the medicine and may cause a delay in the results. 

These factors may include age, overall health, eating habits, and lifestyle.


Age is the most significant factor that affects your sexual health. 

Your metabolism weakens and degrades the immune system as you age. 

A weak immune system is less likely to produce the complete benefits of the medicine. 

It is why older people may not receive as good results as younger individuals.

Dose of medication

The exact benefits of Tadalafil also depend on the strength of the medicine you take. 

A higher strength of Tadalafil will last longer than a lower strength.


Your everyday habits, like smoking and drinking alcohol, may affect how Tadalafil works. 

According to, taking excessive alcohol with Tadalafil may lead to Orthostatic Hypotension. 

Quitting alcohol, smoking, and other forms of substance abuse might help deliver better results from Tadalafil use.

Orthostatic Hypotension is when you experience a sudden blood pressure drop while standing up.

Individual’s overall health

A healthy person with no medical conditions is likelier to receive the best results from Tadalafil. 

This is because any current medicines or underlying conditions may interact with Tadalafil.

If it is the case with you, always speak to your doctor.

Inform your doctor about your complete medical history to get the benefits of this medicine.

Recommended Read: Tadalafil Dosage: How Much Tadalafil Should You Take?

Will taking two Tadalafil help?

No. You should not take two or more Tadalafil pills at the same time. 

According to Pubmed, taking more than one Tadalafil pill might be unsafe.

Taking more than one pill may lead you to overdosing on the medicine. 

It may cause more harm than benefits to your health. 

Stick to your regular dose and consult your doctor if you have any concerns.

Frequently Asked Questions

How long does Tadalafil take to work?

Tadalafil may take 30 minutes to two hours to show its complete effects. 
The exact time the medicine takes to work depends on the individual’s age, lifestyle habits, and overall health.

How long will Tadalafil keep you hard?

Tadalafil may show its effects up to 36 hours after you take it. 
However, the results vary in different individuals and depend on several factors. 
These factors include the individual’s health, eating habits, and any underlying medical conditions.

Is Cialis the same as Tadalafil?

Cialis is the brand name medicine that contains Taladafil as its active ingredient.
In 2023, pharmaceutical giant Lilly ICOS LLC got Tadalafil patented as the brand name Cialis. 
Today, Tadalafil is available under brand names and generic medicines.

How long does 10mg of Tadalafil last?

The 10 mg dose of Tadalafil lasts for about 36 hours. 
It’s possible that Tadalafil’s complete effects will vary from person to person.

What is the best time to take Tadalafil?

You should take Tadalafil at least 30 minutes before having sexual intercourse. 
The medicine may take anywhere between 30 minutes to two hours to show its complete effects.
Take the medicine as advised by your doctor to get the best results.

Cheap Medicine Shop only refers to credible, authoritative sources for our content. If you’re curious about how we ensure the integrity of our content, we encourage you to read our Content Information Policy.

How useful was this post?

Click on a star to rate it!

Average rating 4.5 / 5. Vote count: 216

No votes so far! Be the first to rate this post.

Photo of author Janet Fudge
Janet Fudge is a highly skilled and experienced pharmacologist who serves as a contributing writer for With a strong academic background from a premier US University and a passion for helping others, Janet has become a trusted voice in the pharmaceutical world. After completing her Doctor of Pharmacy degree, Janet embarked on a successful career in the pharmaceutical industry, working with various clients, including hospitals, retail pharmacies, and drug manufacturers. Her in-depth knowledge of pharmacology and dedication to patient-centered care has led her to excel in her field. As a writer for, Janet uses her wealth of expertise to provide readers with accurate, reliable, and up-to-date information on various topics related to medicine and healthcare. Her engaging writing style and ability to break down complex topics into easily digestible content make her a valuable resource for healthcare professionals and the general public.
Please enable JavaScript in your browser to complete this form.

We’d Love To help

Reach out to us we will get back to you

Preferable Time