Erectile Dysfunction (ED) is a medical issue that affects millions of men all around, often leading to stress, relationship problems, and reduced self-confidence. While it is more common with age, ED can occur at any stage of life.
One of the most trusted and widely used treatments for ED is Sildenafil, a prescription medication. Originally developed for heart-related chest pain, Sildenafil gained Food and Drug Administration approval (FDA) in 1998 for the treatment of Erectile Dysfunction.
Since then, it has transformed the way doctors approach this condition. It is also used in the treatment of Pulmonary Arterial Hypertension (PAH), a High Blood Pressure that affects the lungs and heart.
In this article, we will read everything you need to know about Sildenafil: how it works, its uses, dosage guidelines, benefits, potential side effects, precautions, and more.
What is Sildenafil?
Sildenafil Citrate also called the blue pill is the active ingredient in Viagra and Revatio. It belongs to a class of medicines known as Phosphodiesterase type 5 (PDE5) inhibitors.
It relaxes the blood vessels and increasing blood flow to some areas of the body, especially the penis in the case of ED. Sildenafil is not an aphrodisiac and will not cause an erection without sexual stimulation. It only helps the body respond better to arousal.
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Medical uses of Sildenafil
Sildenafil is approved for two major conditions:
- Erectile Dysfunction (ED): The most common use of Sildenafil is for treating ED. It helps men with ED achieve and keep an erection long enough for satisfying sexual performance.
- Pulmonary Arterial Hypertension (PAH): Under the brand name Revatio, Sildenafil is also approved to treat PAH. It improves the ability to exercise by relaxing blood vessels in the lungs, allowing the blood to flow easily.
How does Sildenafil work?
Sildenafil blocks the action of an enzyme called PDE5. This enzyme breaks down cyclic Guanosine Monophosphate (cGMP), which helps in relaxing the smooth muscle cells in the blood vessels. When PDE5 is blocked, cGMP levels increase, leading to more blood flow into the penis during sexual arousal.
This leads to a firmer and more sustained erection, provided the person is sexually stimulated.
In cases of PAH, the same mechanism helps improve blood flow in the lungs.
Recommended dosage
Sildenafil is available in various strengths: 25 mg, 50 mg, and 100 mg tablets for ED, and 20 mg tablets for PAH.
Erectile Dysfunction: It should not be taken more than once a day.
- Starting dose: 50 mg taken about 30 to 60 minutes before sexual activity.
- Maximum dose: 100 mg per day.
- Minimum dose: 25 mg if higher doses cause side effects.
Pulmonary Hypertension: The common dose is 20 mg thrice daily, about 4 to 6 hours apart. Always follow your doctor’s instructions regarding the dosage and timing.
How to take Sildenafil?
For best results, take the following measures:
- Take it by mouth with a glass of water.
- It works best when taken on an empty stomach.
- Avoid fatty meals around the time of taking the pill, as this can delay its effect.
- Do not crush or chew the tablet.
How long does Sildenafil last?
Sildenafil usually starts to work within 30 minutes to 60 minutes and lasts for up to 4 hours. However, this doesn’t mean the erection lasts for 4 hours. Instead, the body remains more responsive to sexual stimulation during this period.
The effects may vary based on age, health conditions, and whether the pill is taken with food or alcohol.
Who should not use Sildenafil?
Sildenafil is generally safe for most adult men who experience ED. However, it may not be suitable for everyone.
It should not be used by:
- Those with severe heart or liver problems.
- People who take Nitrates for heart problems like Angina (heart pain).
- Patients with a recent stroke or heart attack.
- Individuals with Low Blood Pressure.
- Anyone allergic to Sildenafil or similar medications.
Side effects of Sildenafil
Most people tolerate Sildenafil well, but some may experience side effects. These usually go away on their own. However, some symptoms may require medical help.
Common Sildenafil side effects include:
- Headache
- Flushing (redness of the face)
- Upset stomach
- Dizziness
- Nasal congestion
- Blurred vision or sensitivity to light
Rare but serious side effects:
- Chest pain
- Sudden vision or hearing loss
- Painful erection or a prolonged erection (that lasts greater than 4 hours)
- Shortness of breath
- Irregular heartbeat
Get immediate medical help if any serious side effects occur.
Interactions
Sildenafil can interact with other medicines, which can lead to side effects or affect its working.
Avoid using Sildenafil with:
- Alpha-blockers (used for High Blood Pressure or prostate problems)
- Other ED medications (like Tadalafil or Vardenafil)
- Ritonavir, ketoconazole, or other CYP3A4 inhibitors
Always inform your doctor about all the medicines and supplements you are taking.
Buying Sildenafil: What you should know?
Sildenafil is a prescription medicine in most countries, like the U.S. It is available under many brand names and as a generic medicine.
Tips to buy safely:
- Always buy from licensed pharmacies like Cheap Medicine Shop.
- Avoid online sellers that offer the medicine without a prescription.
- Look for FDA- or WHO-approved generics if cost is a concern.
Conclusion
Sildenafil has emerged as a reliable and medically approved solution for both Erectile Dysfunction and Pulmonary Arterial Hypertension.
Its ability to increase blood flow makes it highly effective in helping men achieve better sexual performance and improving exercise capacity in patients with PAH. However, like any medication, its use must be guided by proper medical advice.
All users should be aware of the correct dose, side effects, and possible interactions. It is equally important to purchase Sildenafil from licensed and reliable sources to ensure safety and quality.
If you or someone you know is considering Sildenafil for ED or PAH, consult a doctor to find whether it’s the right treatment option. With proper guidance, Sildenafil can contribute to a better quality of life, improved confidence, and enhanced well-being.
Frequently Asked Questions
Is Sildenafil Safe for long-term use?
Yes, Sildenafil is safe for long-term use in most men, provided it is used as directed. Regular visits with a doctor are recommended to monitor its effectiveness and detect any long-term side effects. For PAH, long-term use under medical supervision is also considered safe and beneficial.
Can women take Sildenafil?
No, Sildenafil is not approved for use in women. Some studies have explored its use for female sexual arousal disorders, but results are not conclusive. Women should not take Sildenafil unless specifically prescribed for off-label use by a healthcare provider
Does Sildenafil increase sexual desire?
No, Sildenafil does not increase sexual desire or libido. It only helps improve the physical response when stimulated sexually by increasing the flow of blood to the penile area. Sexual arousal is still necessary for it to work. Sildenafil is not an aphrodisiac or hormone-based medication.
What should I do if Sildenafil doesn’t work?
If Sildenafil does not work after a few attempts, speak with your doctor. The dose may need adjustment, or there could be underlying health issues affecting its effectiveness. Do not increase the dose on your own. Alternative treatments or lifestyle changes may also help improve results.
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