How Does Sildenafil Work: An Informational Guide for You

Sildenafil is a medication to treat Erectile Dysfunction or ED in men or assigned males at birth (AMAB).

ED is caused by various factors, including physical and psychological causes. 

Regardless of the cause, ED occurs when the blood vessels in the penis become narrow. As a result, it reduces blood flow to the penis, making it difficult to achieve an erection.

But the main question arises here is – How does sildenafil Work to treat ED? What does it do?

It is a Phosphodiesterase type 5 (PDE5) inhibitor, which works by increasing blood circulation to the penis.

This increased blood circulation helps a man attain and sustain an erection after sexual stimulation occurs.

Let’s dive deep to know how does sildenafil work, along with how much time it takes to work and what factors can affect the working of this medicine.

How does Sildenafil work

Sildenafil: how it worksSource: syda_production
Man is thinking

Sildenafil, as mentioned above, is a Phosphodiesterase 5 (PDE5) inhibitor.

When PDE5 is inhibited, cyclic Guanosine Monophosphate (cGMP) levels increase. 

It causes the smooth muscle in the penis to relax and blood vessels to expand.

This process allows more blood to flow through the penis, making it swell and causing an erection.

Once the two tubes of penile tissues fill up with blood, the veins narrow, trapping the blood inside and helping a man maintain an erection.

However, it is essential to note that sexual stimulation is necessary for Sildenafil to work.

How long does Sildenafil take to work

Sildenafil starts to work within 30 minutes of consumption, but the peak effects are usually visible after an hour.

However, some factors like an individual’s health and the type of meal consumed before taking Sildenafil decide how long it will take for this medicine to work.

If you consume a high-fat meal, then the absorption rate of Sildenafil can decrease, resulting in delayed onset of action.

Therefore, it is advisable to take this medicine after a light meal or on an empty stomach 30-60 minutes before sexual intercourse.

How does Sildenafil work the best

How does Sildenafil work the bestSource: Henadzi
Outcome of medicine

Sildenafil will work best if consumed 30 to 60 minutes before sexual intercourse.

Additionally, consume it with water on an empty stomach or after a light meal, as high-fat meals are known to reduce the effectiveness of Sildenafil.

Avoid consuming grapefruit juice or alcohol with Sildenafil as they can cause some side effects or reduce the effectiveness of this medicine.

It is essential to consult your healthcare provider and declare your medical history with them. They will inform you about all the potential interactions with Sildenafil, which can reduce its effectiveness or cause unwanted side effects.

Cyclic Guanosine Monophosphate: Cyclic Guanosine Monophosphate (cGMP) is a natural chemical produced in the body that helps to relax the smooth muscle cells in blood vessels.

Frequently Asked Questions

Does Sildenafil work?

Yes, Sildenafil does work to treat Erectile Dysfunction.
It increases the blood flow to the penis, which helps a man get an erection after sexual stimulation occurs.

What does Sildenafil do?

Sildenafil is used in treating Erectile Dysfunction. It works by inhibiting the enzyme Phosphodiesterase type 5 (PDE5).
As a result, it increases cyclic Guanosine Monophosphate (cGMP) and improves blood circulation to the penis.
This process helps an individual achieve and maintain an erection during sexual activity.

How long does Sildenafil work?

Sildenafil’s effects can last for up to 4 hours after taking the medication. However, it depends on an individual’s health.

How fast does Sildenafil work?

Sildenafil can work within 30 minutes of consumption. However, the onset of action depends on an individual’s health and the meal taken before consuming Sildenafil.

Does Sildenafil keep you hard after coming?

No, Sildenafil does not keep you hard after coming. Once you ejaculate, the erection will naturally subside as Sildenafil only helps in achieving an erection.

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Janet Fudge is a highly skilled and experienced pharmacologist who serves as a contributing writer for With a strong academic background from a premier US University and a passion for helping others, Janet has become a trusted voice in the pharmaceutical world. After completing her Doctor of Pharmacy degree, Janet embarked on a successful career in the pharmaceutical industry, working with various clients, including hospitals, retail pharmacies, and drug manufacturers. Her in-depth knowledge of pharmacology and dedication to patient-centered care has led her to excel in her field. As a writer for, Janet uses her wealth of expertise to provide readers with accurate, reliable, and up-to-date information on various topics related to medicine and healthcare. Her engaging writing style and ability to break down complex topics into easily digestible content make her a valuable resource for healthcare professionals and the general public.