Cladrim 10 Mg Injection
| Pack Size | Price | Qty | Unit Price |
|---|---|---|---|
| 2 Injection | $655.50 | $327.75 | |
| 4 Injection | $1,276.80 | $319.20 | |
| 6 Injection | $1,881.00 | $313.50 |
What is Cladrim 10 mg
Cladrim 10 mg is a chemotherapeutic agent used to treat certain types of blood cancers in adult patients. Its primary ingredient is Cladribine, which is a purine nucleoside analog that acts as an antimetabolite.
Cladrim 10 mg is specifically indicated for hairy cell leukemia. However, it may be prescribed for certain types of non-Hodgkin's lymphomas and chronic lymphocytic leukemia that have not responded to standard treatments. The medication works by interfering with DNA synthesis in both dividing and resting lymphocytes, leading to cell death in both active and dormant cancer cells.
Fresenius Kabi India Pvt Ltd is the renowned manufacturer of Cladrim 10. The medication requires administration by healthcare professionals in controlled clinical settings with careful monitoring due to its potential for significant myelosuppression, neurotoxicity, and immunosuppressive effects that may increase infection risk.
What are the benefits of Cladrim 10 mg
Cladrim 10 mg delivers Cladribine, which functions as a prodrug that enters cells and is activated through phosphorylation by deoxycytidine kinase. Once activated, it incorporates into DNA, inhibiting DNA synthesis and repair mechanisms, ultimately triggering apoptosis (programmed cell death).
This mechanism is particularly effective against both proliferating and quiescent lymphoid cells, making it uniquely suited for treating certain hematological malignancies.
Cladrim is used for treating:
- Hairy cell leukemia (particularly in patients who have failed standard treatments).
- Certain B-cell chronic lymphocytic leukemias.
- Specific non-Hodgkin's lymphomas, especially indolent types.
- Cutaneous T-cell lymphomas in selected cases.
It is crucial to note that Cladrim requires careful administration with specialized monitoring for potential bone marrow suppression and opportunistic infections.
How to take Cladrim 10 mg
Cladrim injection is a prescription medication that should be administered only by qualified healthcare professionals.
- Cladrim can be given as an intravenous (IV) infusion or as a subcutaneous injection.
- IV infusion is given over a period of 2 hours.
- The dosage depends on individual factors and the condition being treated.
- Do not self-administer.
Strength and substitutes
Currently, no strength alternatives or substitutes are available for Cladrim 10 at Cheap Medicine Shop.
What are the side effects of Cladrim 10 mg
Cladrim can cause significant side effects that require careful monitoring. Common side effects include:
- Fever
- Nausea and vomiting
- Headache
- Fatigue and weakness
- Skin rash or reactions
These adverse effects resolve quickly. However, they may require medical supervision if they persist.
Safety Advice
People with hepatic impairment should be treated with caution. Liver function tests should be performed before treatment initiation and regularly monitored during therapy. Dose reduction may be necessary in those with moderate to severe hepatic dysfunction. Treatment may need to be discontinued if significant hepatotoxicity develops during therapy.
Dose adjustments are recommended for people with moderate to severe renal impairment. Regular monitoring of renal function is essential throughout treatment. Increased hydration may be recommended to facilitate drug excretion and reduce the risk of tumor lysis syndrome.
Cladrim is contraindicated during pregnancy as it may cause fetal harm. Women of childbearing potential and men undergoing treatment should use effective contraception during treatment and for at least 6 months following the final dose. Breastfeeding should also be discontinued during treatment and for at least 1 week after the last dose due to the potential for adverse events in nursing infants.
Alcohol consumption should be avoided during Cladrim treatment as it may increase the risk of liver toxicity and enhance side effects. Due to immunosuppression, live vaccines should be avoided during treatment and for several months afterward. Grapefruit juice may interfere with drug metabolism and should be avoided. Supplements that may affect blood counts or immune function should be discontinued during therapy.
FAQs
How does Cladrim 10 mg Injection work?
Cladrim 10 contains Cladribine, which enters lymphocytes and is activated by cellular enzymes. Once activated, it disrupts DNA synthesis and repair, ultimately triggering cell death in both actively dividing and resting cancer cells, particularly effective against certain blood cancers.
How should Cladrim 10 mg Injection be stored?
Cladrim 10 should be stored in a refrigerator (2-8°C) in its original packaging, protected from light. Do not freeze. Once diluted for infusion, the solution should be used within 8 hours if stored at room temperature or 24 hours if refrigerated.
What are the common side effects of Cladrim 10 mg Injection?
The most common side effects of Cladrim include fever, fatigue, nausea, decreased blood cell counts (increasing infection and bleeding risk), headache, and skin rash. Most patients experience some degree of myelosuppression, which requires regular blood monitoring throughout treatment.
Are there any dietary restrictions while using Cladrim 10 mg Injection?
There are no specific dietary restrictions for Cladrim, but maintaining good nutrition is important. Patients should avoid grapefruit products as they may interfere with drug metabolism. A balanced diet rich in proteins and calories helps support recovery during treatment periods.
What should I do if I develop a fever during Cladrim 10 mg treatment?
Contact the healthcare provider immediately if you develop a fever of 100.4°F (38°C) or higher. Fever during treatment may indicate infection, which requires prompt evaluation due to your compromised immune system. Don't take fever-reducing medications before consulting your doctor.
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