What is Flutrol 100 capsule

Flutrol 50 mcg/100 mcg capsule is a combination dry powder inhalation capsule containing FDA-approved Salmeterol (50 mcg) and Fluticasone Propionate (100 mcg) as its active ingredients. Macleods Pharmaceuticals Pvt Ltd manufactures the capsules in GMP-compliant facilities.

Salmeterol is a Long-acting Beta-2 Adrenergic Agonist (LABA), and Fluticasone Propionate is an Inhaled Corticosteroid (ICS). Together, they provide complementary mechanisms of action for Chronic Obstructive Pulmonary Disease (COPD) and Asthma.

Salmeterol works by selectively binding to beta-2 adrenergic receptors on the smooth muscle of the bronchial walls, causing sustained relaxation of the airway muscles and prolonged widening of the bronchial passages. Unlike short-acting bronchodilators, Salmeterol provides up to 12 hours of bronchodilation, making it suitable for twice-daily maintenance dosing to prevent the onset of Bronchospasm, wheezing, and breathlessness rather than treating acute episodes.

Fluticasone Propionate acts on glucocorticoid receptors within the airway lining cells to suppress the release of inflammatory agents such as histamines, cytokines, and prostaglandins. This reduces mucosal swelling, mucus hypersecretion, and airway hypersensitivity that drive the chronic inflammatory component of Asthma and COPD.

The capsules are intended for use with a compatible dry powder inhaler device and must not be swallowed. Each capsule is pierced inside the device, and the powder is inhaled into the lungs. While generally safe, they can cause side effects, including throat irritation, hoarseness, oral thrush, headache, and palpitations.

Before starting Flutrol 100 capsules, inform a doctor of any history of cardiovascular disease, Hypertension, Diabetes, Hyperthyroidism, or known hypersensitivity to either active ingredient, as these can affect treatment suitability or require additional monitoring. Store the capsules in a cool, dry place below 25°C, away from moisture and sunlight.

What are the benefits of taking Flutrol 100 capsule

Flutrol 100 capsules provide clinically meaningful respiratory benefits for patients requiring consistent, long-term control of obstructive airway conditions. Some of them include:

• Long-acting bronchodilation: Salmeterol sustains relaxation of bronchial smooth muscle for up to 12 hours per dose, preventing airway narrowing, wheezing, and breathlessness and supporting twice-daily maintenance dosing for consistent symptom control.
• Sustained airway inflammation control: Fluticasone Propionate suppresses the chronic inflammatory response in the airways, reducing mucosal swelling, mucus production, and bronchial hypersensitivity that contribute to ongoing respiratory symptoms in both Asthma and COPD.
• Dual-action in a single inhalation: The combination of a LABA and an ICS in one capsule addresses the two primary pathological processes of obstructive airway disease simultaneously, simplifying the treatment regimen and improving adherence compared to using two separate inhalers.
• Asthma and COPD maintenance: Regular use of Flutrol 100 capsules reduces the frequency of acute attacks, decreases the need for rescue bronchodilators, and supports improved lung function and quality of life in patients with chronic respiratory conditions.

How to use Flutrol 100 capsule

Flutrol 100 capsule is a prescription medication that should be used as directed by a healthcare professional. Here are the general guidelines:

• Inhale the contents of 1 Flutrol capsule twice daily, in the morning and evening, with a compatible dry powder inhaler device, at approximately the same times each day, or as directed by a doctor.
• Place the capsule into the device, pierce it as instructed, breathe out gently away from the device, then inhale deeply and steadily through the mouthpiece to draw the powder into the lungs. Hold the breath for nearly 10 seconds before exhaling.
• Rinse the mouth with water and spit it out after each inhalation to prevent oral thrush from the corticosteroid component. Do not swallow the capsules.
• Do not exceed the prescribed frequency or dosage. Flutrol 100 capsule is a maintenance medication and must not be used as a rescue inhaler for sudden breathing attacks.

Strengths and Substitutes

Flutrol is available in multiple strengths, substitutes, and types at Cheap Medicine Shop. You can consider the following alternatives:

View all substitutes

What are the side effects of the Flutrol 100 capsule

Flutrol 100 capsule can cause some mild side effects that generally subside as the body adjusts to treatment. However, consult a healthcare professional if they persist or worsen:

• Throat irritation or hoarseness
• Oral thrush if the mouth is not rinsed after use
• Headache
• Palpitations or increased heart rate
• Tremors
• Coughing after inhalation
• Nausea

Safety Advice

Liver Disease

Flutrol 100 capsule should be used with caution in patients with liver disease. Fluticasone Propionate is extensively metabolized in the liver, and impaired function may reduce its clearance, raising the risk of side effects. Although these interactions are not well-established with inhaled medicines, inform a doctor of any liver conditions before starting treatment.

Kidney Impairment

Flutrol 100 capsule may be used with caution in patients with kidney disease. As an inhaled combination therapy, systemic absorption is limited. However, the cardiovascular effects of Salmeterol and potential electrolyte changes need to be evaluated. Inform a doctor of any kidney conditions before initiating therapy.

Pregnant and Breastfeeding women

Flutrol 100 capsule should be used during pregnancy only when a doctor determines that the benefits outweigh the potential risks. Both Salmeterol and Fluticasone Propionate can pass into breast milk in small amounts. So, breastfeeding women should consult a doctor to evaluate whether continued use is appropriate.

Avoid

Do not use Flutrol capsules as a rescue medication for Acute Bronchospasm or sudden Asthma attacks, as Salmeterol does not provide rapid enough bronchodilation for emergency use. Avoid use in patients with known hypersensitivity to Salmeterol, Fluticasone Propionate, or any inactive capsule ingredient. Do not use it concurrently with other long-acting beta agonists. Inform a doctor of all current medications, particularly beta-blockers, which may reduce the bronchodilator effect of Salmeterol, and diuretics or other medications affecting potassium levels, as concurrent use may increase the risk of Hypokalemia (low potassium levels).