What is Pradaxa 75 mg capsule

Pradaxa 75 mg is an anticoagulant medication used to prevent blood clots and reduce the risk of stroke in people with Non-Valvular Atrial Fibrillation (NVAF). It also treats other medical conditions, Pulmonary Embolism (PE) and Deep Vein Thrombosis (DVT).

Its active ingredient, Dabigatran Etexilate (75mg), belongs to the direct thrombin inhibitor class of drugs. It works by blocking the activity of thrombin, a key enzyme in blood clot formation.

Boehringer Ingelheim is the leading manufacturer of Pradaxa 75. This oral anticoagulant may cause side effects such as bleeding, gastrointestinal discomfort, and allergic reactions. It should be stored at room temperature in its original packaging to protect it from moisture.

Patients should not discontinue Pradaxa without consulting their doctor, as this can increase stroke risk. Regular kidney function monitoring is essential as the medicine is primarily eliminated through the kidneys. Also, discuss medicine and medical history with a doctor for safety.

What are the benefits of Pradaxa 75 mg capsule

Pradaxa 75 mg is a direct thrombin inhibitor, binding specifically to thrombin molecules that play a vital role in the blood coagulation cascade. Unlike traditional anticoagulants like Warfarin, which affect multiple coagulation factors, Dabigatran targets only thrombin, potentially offering more predictable anticoagulation effects.

Pradaxa provides several therapeutic benefits:

• Reduces stroke risk in those with Non-valvular Atrial Fibrillation.
• Prevents deep vein thrombosis and pulmonary embolism.
• Requires no routine blood monitoring of INR levels, unlike Warfarin.
• Has a rapid onset of action and predictable anticoagulant effect.

It is crucial to note that while Pradaxa effectively prevents clots, it increases bleeding risk and should be temporarily discontinued before surgical procedures or dental work.

How to take Pradaxa 75 mg capsule

Pradaxa is a prescription medication that should be taken as per your doctor's instructions. Here are the general guidelines:

• Take Pradaxa 75 capsules twice daily, approximately 12 hours apart.
• Swallow the capsule whole with water; do not break, crush, or empty the contents.
• Take Praxada with or without food, but try to take it at the same time each day for optimal effectiveness.
• If a dose is missed, take it as soon as possible on the same day; do not double the dose.
• Do not exceed the prescribed dosage of these capsules.

Do not discontinue Pradaxa without consulting your doctor, as this may increase stroke risk.

Strength and substitutes

The strength and substitutes available for Pradaxa are:

View all substitutes

What are the side effects of Pradaxa 75 mg capsule

Pradaxa is generally effective when used as prescribed. However, it may cause side effects, including:

• Bleeding (including bruising, nosebleeds, or blood in urine or stool)
• Gastrointestinal symptoms like nausea, indigestion, or stomach pain
• Allergic reactions, including rash, itching, or difficulty breathing
• Headache or dizziness

These adverse effects should be monitored closely; any signs of unusual or severe bleeding require immediate medical attention.

Safety Advice

Liver disease

Pradaxa should be used with caution in patients with liver disease. Regular liver function tests are needed before and during treatment. No dosage adjustment is typically required for mild to moderate hepatic impairment.

Kidney impairment

Pradaxa is primarily eliminated through the kidneys. For patients with moderate renal impairment, the 75 mg dose is often appropriate. Pradaxa is not recommended for patients with severe kidney disease (CrCl <30 mL/min). Regular kidney function monitoring is essential during treatment.

Pregnant and breastfeeding women

Pradaxa is not recommended during pregnancy as it may harm the developing fetus, particularly in the second and third trimesters. It is classified as FDA Category C (for the first trimester) and D (for the second and third trimesters). Pradaxa should not be used while breastfeeding as it may pass into breast milk.

Avoid

Grapefruit juice may increase Dabigatran levels and should be avoided. Concurrent use with other anticoagulants, antiplatelet drugs, or NSAIDs significantly increases bleeding risk. Certain P-glycoprotein inhibitors like Ketoconazole and Dronedarone can increase Dabigatran levels and should be used cautiously or avoided altogether.