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What Are Tadalafil’s Effects On Kidneys?

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According to the NIDDK, around 30 million men in the US are affected by Erectile Dysfunction.

Tadalafil is the active component in Cialis.

Cialis is commonly used to treat Erectile Dysfunction (ED) and Benign Prostatic Hyperplasia (BPH) in men.

It also helps treat the symptoms of Pulmonary Arterial Hypertension in men and women.

There are not many studies available on the effects of Tadalafil on kidneys.

But, it is a medication with a long history of safe and effective use.

We’ve discussed Tadalafil and its effect on the kidneys below.

About Tadalafil

Tadalafil is an inhibitor of the Phosphodiesterase type 5 (PDE5) enzyme.

It increases penile blood flow by inhibiting the PDE5 enzyme.

Finding the correct dosage of Tadalafil is essential if you want to use it.

It will assist you in achieving and sustaining an erection.

The prices of generic Tadalafil are lower than those of Cialis.

Effects of Tadalafil on the Kidneys

Cialis is generally safe for use by men with kidney problems.

But more research is required to understand its effects on the kidneys better.

Various studies are available on rats with renal issues and Tadalafil’s effect on them. 

The study found that high-dose of Tadalafil had a positive impact on renal blood flow and blood pressure.

Tadalafil has demonstrated promising results in rats with Chronic Kidney Disease (CKD). 

Studies indicate that PDE5 inhibitors may help preserve kidney function and prevent CKD development.

These studies on rats are hopeful, but more work is needed to know the effects on people with CKD.

Tadalafil is often used to treat ED in men with CKD.

But you should consult a doctor before taking Tadalafil.

Ciralis is known as the ‘weekend pill’ because its effects last for around 36 hours.

Safe use of Tadalafil

Person suffering with heart problemSource: Nenad_Cavoski_from_Getty_Images
Heart problem

Men with kidney problems may use Tadalafil without much risk.

When taking Tadalafil, listening to what your doctor tells you is important. 

Here are some tips for using Tadalafil safely:

  • People with heart problems should consult a doctor before taking Tadalafil.
  • Do not take Tadalafil more than once in 24 hours. Talk to your doctor before raising your dosage.
  • If you take Tadalafil regularly, don’t take two doses to compensate for a missed dose.
  • Don’t drink grapefruit juice or alcohol with Tadalafil, as it may lead to side effects.
Tadalafil is a prescription-only medication. Do not buy it over the counter, as you may end up with counterfeit medication.

Kidney problems and ED

Problems with the kidneys can influence the health of other organs in the body.

Kidney disease may impact hormone levels, circulation, and nerve function, influencing erectile function.

Certain medications, energy levels, and lifestyle choices may cause ED in men.

Problems with the kidneys can contribute to a buildup of toxic waste, which can affect sexual function.

Tell your doctor about your kidney problems before taking any ED medication to avoid interactions.

Read the following article for the correct Tadalafil dosage: Tadalafil Dosage: How Much Tadalafil Should You Take?

To Sum Up

Kidney disease can cause ED due to changes in hormone levels, nerve damage, or blood waste products. 

Mental health issues and certain medications may also cause ED.

Tadalafil is safe for most men with kidney difficulties. 

More study is needed to learn what are Tadalafil’s effects on kidneys in humans.

But several studies are present on how Tadalafil affects rats with kidney problems.

Frequently Asked Questions

What is the maximum dose of Tadalafil in 24 hours?

20 mg of Tadalafil is the most that you can take in a single day. It would be best if you only took Tadalafil once per day and not more than that.

How much Tadalafil should I take?

As needed, Tadalafils’ usual beginning dose is 10 mg. 
Depending on how you respond to the dose, your doctor will modify it. 
Take at most one dose daily to reduce your risk of experiencing side effects.

Who should avoid taking Tadalafil?

Individuals taking nitrates such as nitroglycerin tablets or patches should avoid taking Tadalafil. Combining these with Cialis may result in fainting or even death in some men.

What happens if I take two Tadalafil pills?

Doubling the maximum dose of Tadalafil can increase the chances of experiencing side effects. These include: 

When should I take Tadalafil for the best results?

You should take your Tadalafil dose before sexual activity for the best results.
Depending on your preference, you can take Tadalafil with or without food.

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Jim Carson is a highly skilled and dedicated medical writer passionate about advancing medical practice. With years of experience in the field of medical sciences, Jim has made significant contributions to various studies aimed at improving healthcare outcomes. He currently writes for, providing expert insights and knowledge on various topics. Jim's expertise extends to various areas, including drug interactions, dosages, side effects, and best practices for medication use. In Los Angeles, Jim lives with his loving wife, children, and beloved pets. He deeply values spending time with his family and cherishes their presence. When he's not writing, Jim enjoys watching football games and staying updated with the latest sports news. Jim's writing shines through his commitment to advancing medical practice and improving healthcare outcomes. Readers can trust Jim's articles to be informative, accurate, and reliable, making him a trusted pharmaceutical information source for the website's audience.
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