Lispro 2.5 Mg Tablet
| Pack Size | Price | Qty | Unit Price |
|---|---|---|---|
| 100 Tablet/s | $17.00 | $0.17 | |
| 200 Tablet/s | $32.00 | $0.16 | |
| 300 Tablet/s | $45.00 | $0.15 |
What is Lispro 2.5 mg tablet
Lispro 2.5 mg is primarily prescribed for mild Hypertension, as initial therapy for sensitive populations such as elderly patients or those with renal insufficiency, and as adjunctive therapy in heart failure management. It is a carefully formulated medication containing Lisinopril (2.5 mg).
Its active constituent belongs to the Angiotensin-converting Enzyme (ACE) inhibitor class of pharmaceuticals. Johnlee Pharmaceuticals Pvt Ltd, a reputable pharmaceutical company, manufactures this specialized low-dose formulation.
The pharmacological action involves inhibiting the enzyme that converts angiotensin I to the vasoactive peptide angiotensin II. Patients may experience adverse effects, including initial dizziness, mild headache, fatigue, and occasional gastrointestinal disturbances. More serious effects, like Angioedema or alterations in blood cell counts, may occur in rare cases.
Lispro 2.5 mg should be stored at room temperature (15-30°C) in a dry place, protected from light. This medication requires special consideration in patients with autoimmune disorders, Hyperkalemia, or severe Aortic Stenosis.
Regular blood pressure, renal parameters, and electrolyte balance monitoring are essential, particularly during the initial treatment phase and following any dosage adjustments.
What are the benefits of Lispro 2.5 mg tablet
Lispro 2.5 mg exerts its therapeutic effects by selectively inhibiting the Angiotensin-converting Enzyme, disrupting the renin-angiotensin-aldosterone cascade. This results in decreased production of angiotensin II and subsequent reduction in aldosterone secretion. The lower dosage strength allows for gentle initiation of therapy and precise dose titration according to individual patient response.
This specialized formulation offers distinct advantages:
- Gentle blood pressure reduction: Provides gradual and sustainable lowering of blood pressure, ideal for sensitive patients.
- Cardiac remodeling prevention: Slows ventricular hypertrophy progression and improves cardiac geometry.
- Nephroprotection: Reduces intraglomerular pressure and proteinuria, preserving kidney function.
- Improved prognosis: Decreases risk of cardiovascular events in high-risk patients.
- Metabolic neutrality: Minimal impact on glucose metabolism compared to other antihypertensive classes.
It is essential to understand that Lispro 2.5 tablets represent an initial or maintenance dose and may require upward adjustment based on therapeutic response and patient tolerance.
How to take Lispro 2.5 mg tablet
Lispro 2.5 mg is a prescription medication that should be taken as per your doctor's instructions. Here are the general guidelines:
- Take one Lispro 2.5 tablet once daily, preferably at the same time each day. To minimize the first dose effect, take the initial dose at bedtime.
- Swallow whole without breaking or chewing with water.
- The tablet can be taken with or without food.
- Do not discontinue abruptly without medical consultation. Do not exceed the prescribed dose.
Strengths and substitutes
The strengths and substitutes available for Lispro 2.5 mg at Cheap Medicine Shop are:
| $2.00 / 10 tablets | |
| $5.50 / 10 tablets |
What are the side effects of Lispro 2.5 mg tablet
Lispro 2.5 mg is generally well-tolerated at this lower dosage. However, it may cause side effects, including:
- First-dose Hypotension/low blood pressure (particularly in volume-depleted patients)
- Persistent, non-productive cough
- Mild gastrointestinal disturbances like nausea or diarrhea
- Hyperkalemia (elevated potassium levels)
- Headache or mild fatigue
These adverse effects are typically mild and diminish over time. However, certain symptoms require immediate medical attention, including facial swelling, difficulty breathing, chest pain, or severe dizziness/fainting.
Safety Advice
Patients with hepatic impairment may experience altered drug metabolism, though significant dosage adjustments are typically unnecessary for Lispro. Nevertheless, patients with severe liver dysfunction should be monitored closely for signs of excessive Hypotension. Periodic liver function testing is recommended, particularly during the initial three months of therapy.
Lispro 2.5 is primarily eliminated through renal excretion, making dosage considerations crucial in patients with kidney impairment. For patients with mild to moderate renal insufficiency, 2.5 mg represents an appropriate starting dose. Those with severe impairment (creatinine clearance <10 mL/min) may require alternate-day dosing. Regular monitoring of renal function and electrolytes is essential.
Lispro is contraindicated during pregnancy due to documented risks of fetal developmental abnormalities, particularly during the second and third trimesters. Exposure during pregnancy has been associated with oligohydramnios, neonatal Hypotension, renal failure, and skull hypoplasia. Women planning pregnancy should switch to alternative antihypertensive treatments. Limited data suggests Lisinopril appears in breast milk, so alternative feeding or medication options should be considered.
Avoid concurrent use of lithium as Lispro may increase lithium levels, potentially leading to toxicity. NSAIDs may reduce the antihypertensive efficacy and increase the risk of renal deterioration. Potassium-sparing diuretics or supplements should be used cautiously due to hyperkalemia risk. Excessive dietary salt restriction may potentiate hypotensive effects, leading to dizziness or fainting.
FAQs
How long does it take for Lispro 2.5 mg tablet to show effects?
Some patients may notice initial blood pressure reduction within 6-8 hours after the first dose. However, the full antihypertensive effect develops gradually over 3-4 weeks of consistent daily administration. This gradual onset minimizes side effects and allows for physiological adaptation.
How does Lispro 2.5 mg tablet help in managing high blood pressure?
Lispro 2.5 mg inhibits the conversion of angiotensin I to angiotensin II, reducing vasoconstriction and aldosterone production. This dual mechanism promotes vasodilation, decreases peripheral resistance, reduces sodium and water retention, and lowers blood pressure without significantly affecting heart rate.
Why is Lispro 2.5 mg prescribed at a lower dose than other Lisinopril formulations?
The 2.5 mg strength is specifically designed for sensitive populations such as elderly patients, those with renal impairment, or patients on diuretic therapy. This lower dose minimizes first-dose Hypotension risk and allows for careful titration based on individual response and tolerability.
Can Lispro 2.5 mg affect my potassium levels?
Yes, Lispro 2.5 mg can cause potassium retention by reducing aldosterone production. While this effect is generally mild at the 2.5 mg dose, patients should monitor for symptoms of hyperkalemia like muscle weakness or irregular heartbeat, especially if taking potassium supplements or potassium-sparing medications.
How should I transition from other blood pressure medications to Lispro 2.5 mg?
Transitioning typically requires temporary discontinuation of previous medications, particularly other ACE inhibitors or ARBs, followed by initiation of Lispro 2.5 mg. If beta-blockers are being discontinued, they should be tapered gradually. Always follow your doctor's specific transition plan, which may include a medication-free interval and close blood pressure monitoring.
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