Assurans 10 mg/12.5ml Injection
| Pack Size | Price | Qty | Unit Price |
|---|---|---|---|
| 1 Injection | $38.00 | $38.00 | |
| 2 Injection | $73.72 | $36.86 | |
| 3 Injection | $106.02 | $35.34 |
What is Assurans Injection
Assurans injection contains Sildenafil, an FDA-approved ingredient. It is used to treat Pulmonary Arterial Hypertension (PAH) and belongs to the medicine class of Phosphodiesterase Type-5 (PDE-5) inhibitors. Cipla Ltd. manufactures Assurans 10 mg injection.
Sildenafil Citrate Injection functions by selectively blocking the PDE-5 enzyme in the lungs' smooth muscles. By doing so, cyclic Guanosine Monophosphate (cGMP) levels elevate, resulting in muscle relaxation. This reduces blood pressure and eases heart strain.
A doctor's consultation is required to administer this injectable medicine. Usually, 10 mg of Sildenafil is injected 3 times a day, with a 4- 6 hour gap in between.
It has some common side effects that are temporary. These include dizziness, muscle ache, and headache. Consult a doctor if they persist for a long time.
The injection should be stored below 30 °C. Avoid freezing and protect it from light. Keep pets and children out of reach.
There are a few interactions to watch for. Organic Nitrates, such as Nitroglycerin, can cause a severe drop in blood pressure. Strong CYP3A4 (enzyme that processes medicines in the body) inhibitors, such as Ritonavir or Ketoconazole, also show interaction. They increase Sildenafil levels and boost the chances of side effects.
A few other medicines that interact with injectable Sildenafil are Alpha-blockers (Tamsulosin or Doxazosin) and medicines for reducing blood pressure. These can significantly decrease blood pressure. Consult a healthcare professional before using them.
What are the benefits of taking Assurans Injection
Injectable Sildenafil therapy offers several benefits, particularly in treating PAH. Given below are these benefits:
- It treats PAH by dilating and relaxing blood vessels in the lungs.
- It eases the heart's workload by lowering High Blood Pressure in the lungs.
- It helps individuals breathe easier by enhancing exercise capacity.
- It prevents clinical worsening of PAH symptoms.
- It is an effective alternative for individuals who can't take oral Sildenafil.
- It improves the quality of life for PAH patients.
How to take Assurans Injection
Assurans is a prescription PAH medication. Hence, you are advised to take it exactly as directed by the doctor. Given below are the general dosage guidelines:
- Inject the medication 3 times a day.
- Ensure a 4-6 hour gap between the doses.
- Inject the dose slowly into a vein. The usual administration site is the arm.
- Take the medication at around the same time every day.
Note: Avoid self-administration to prevent any risk. Seek the help of a medical professional.
Strengths and Substitutes
Currently, only substitutes are available at Cheap Medicine Shop:
| Metolar 100 mg | $2.30/10 tablets |
| Aldactone 100 mg | $4.70/10 tablets |
| Amlip 5 mg | $1.80/10 tablets |
What are the side effects of Assurans Injection
It can cause side effects that are generally temporary and mild. These common effects are:
- Nasal congestion
- Heartburn
- Headache
- Tingling in the feet, legs, arms, and hands
- Muscle pain
- Flushing
Note: Call your doctor immediately if you experience severe side effects, such as chest pain, hives, swelling of the face, or loss of vision.
Safety Advice
Use with caution in case of liver conditions, particularly severe ones. Sildenafil is processed by the liver, and impaired liver function can impact medication elimination, increasing the risk of side effects.
Dose adjustments might be needed in individuals with severe kidney disorders. Regular monitoring is also necessary, as Sildenafil elimination is reduced when the kidneys malfunction.
Due to limited safety data for the injectable form in breastfeeding and pregnant women, use only when a doctor prescribes the medication.
Avoid grapefruit juice as it is known to elevate the levels of Sildenafil and increase the risk of side effects. Also, avoid alcohol as it can trigger a series of other side effects.
FAQs
How long does Sildenafil take to work for Pulmonary Hypertension?
The injectable form of Sildenafil starts showing its effect generally 5-20 minutes after injection for Pulmonary Hypertension. The effect can last for 4 or more hours. Its quick onset makes this form extremely useful in hospital or acute settings where rapid PAH management is needed.
When was Sildenafil approved for PAH?
The US Food and Drug Administration (FDA) approved Sildenafil (oral form) for PAH on June 3, 2005. Later, in 2009, the injectable form for PAH treatment was approved to offer an alternative administration route for individuals who can't take the oral form.
Can Sildenafil cause shortness of breath?
Yes, Sildenafil can cause shortness of breath, which is one of its possible side effects. However, it is not very common. Individuals using Sildenafil for PAH have reported shortness of breath. It could be associated with the medication's impact on blood pressure or an underlying heart issue.
Is Sildenafil a steroid or not?
No, Sildenafil is not a steroid. It belongs to the PDE-5 inhibitor medication class. Unlike steroids, Sildenafil has no hormone-like effects and in no way impacts steroid hormone pathways. Its key mode of action is to suppress the PDE-5 enzyme.
Can a diabetic patient take Sildenafil?
Yes, diabetic patients can take Sildenafil for PAH treatment under medical supervision. Clinical studies have revealed that Sildenafil is usually well-tolerated and effective in adults having PAH, including those who may have Diabetes.
Does Sildenafil give you energy?
Yes, Sildenafil can indirectly help enhance energy by lowering muscle fatigue and improving exercise capacity, particularly in individuals with conditions such as PAH or other cardiopulmonary issues. However, it does not function like stimulants to provide direct energy.
Can Sildenafil cause memory loss?
Yes, Sildenafil can cause temporary memory loss. It is a very rare side effect that has been reported in isolated case reports. Temporary episodes of memory loss can rarely occur, but they resolve within 24 hours. Consult a doctor if this effect persists.
Citation: MedlinePlus
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