Sertraline for Premature Ejaculation: Is It An Effective Treatment 

Thirty percent of men or Assigned Males at Birth (AMAB) are unable to engage in sexual activity for a longer time and ejaculate very early due to Premature Ejaculation.

However, the good news is PE can be treated by taking medicines such as antidepressants prescribed by the doctor.

There are several antidepressants available, including Zoloft and Lustral. These meds contain Sertraline as a key ingredient.

So, can you take Sertraline for Premature Ejaculation as well? The answer is yes. 

You may take Sertraline to treat Premature Ejaculation. It might be effective for the treatment of PE.

In the following sections, we will learn more about Sertraline, its side effects, and its dosage for treating PE.

Sertraline for Premature Ejaculation

Sertraline is an FDA-approved Selective Serotonin Reuptake Inhibitors (SSRI) for treating Depression, Obsessive-Compulsive Disorder (OCD), and Post Traumatic Stress Disorder (PTSD).

Although the FDA has not approved Sertraline for treating PE, it is often prescribed off-label for treating PE effectively.

Sertraline helps in increasing the levels of neurotransmitters called Serotonin.

Serotonin is essential for your sexual function, sleep, and mood. And according to Urology Care Foundation, low levels of Serotonin can cause PE.

Various studies have mentioned the effectiveness of 50mg of Sertraline for treating PE. Individuals who took that dosage could see improvements in their ejaculation time. 

A review of studies stated the efficacy of Sertraline for managing PE. It was found that Sertraline was able to improve ejaculation time and sexual satisfaction. 

A study published in 2021 compared the effectiveness of taking Sertraline daily vs. taking it 4 hours before sex (on-demand).

Both methods help increase ejaculation time significantly. However, the daily usage of the medication increased ejaculation time more as compared to taking it on-demand.

A study mentioned the suitable dosage of Sertraline for the treatment of PE. According to that study,  25mg, 50mg, and 100mg of dosages can help with PE.

It is advised to seek medical advice for an effective dosage for your PE.

SSRI: Selective Serotonin Reuptake Inhibitors or SSRIs are a class of antidepressants that aids in treating Anxiety and Depression.
Off-label: A medicine is called off-label when prescribed for treating a condition it is not approved to treat.

What are the effects and interactions of Sertraline

Nausea - Sertraline common side effectSource: AndreyPopov_from_Getty_Images
Nausea – Sertraline’s common side effect

Sertraline is generally safe and effective for most individuals in treating Premature Ejaculation.

However, just like other medicines, it also has some side effects that may affect some individuals.

Following are some common and rare side effects of Sertraline-

Common side effects of SertralineRare side effects of Sertraline
Dry mouth
Trouble sleeping
Upset stomach
Excessive bleeding
Intrusive thoughts
Certain heart rhythm problems

Although Sertraline helps in improving sexual functions, it may cause Erectile Dysfunction and Serotonin Syndrome.

Apart from side effects, Sertraline may interact with several medicines and health conditions.

According to, Sertraline can interact with-

  • Benadryl (Diphenhydramine)
  • Vyvanse (Lisdexamfetamine)
  • SSRIs like Citalopram, Escitalopram, Paroxetine
  • Seroquel (Quetiapine)
  • Eliquis (Apixaban)
  • Aspirin Low Strength (Aspirin)

Sertraline can also interact with these health conditions-

  • Hyponatremia
  • Glaucoma
  • Liver disease
  • Mania
  • Seizure disorders
  • Renal Dysfunction
  • Weight loss

If you are unable to treat your PE with Sertraline due to its side effects and interactions, you may try Dapoxetine for PE. It is also an SSRI, made specifically to treat PE effectively.

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  • Alternatives of Sertraline for treating Premature Ejaculation

    According to some studies, Sertraline is effective in treating Premature Ejaculation.

    But, due to its side effects and interactions with other medicines, its effectiveness might vary for individuals.

    But the good news is there are other antidepressants, such as Dapoxetine, that may help treat PE effectively.

    Dapoxetine is an SSRI specifically designed for treating Premature Ejaculation effectively.

    A study mentioned SSRIs other than Sertraline were also effective in treating PE. 

    According to Mayo Clinic, apart from Sertraline, the following oral medicines can help manage PE.

    Alternatives of SertralineMedicines Name and overview
    AntidepressantsAntidepressants such as Dapoxetine, Paroxetine (Paxil, Pexeva, Brisdelle), Escitalopram (Lexapro), and Citalopram (Celexa) can be used for treating PE. 
    From these meds, Dapoxetine is often used to treat PE.
    PDE-5 inhibitorsPDE-5 inhibitors such as Sildenafil (Viagra) and Tadalafil (Cialis) may help treat PE. 
    These medicines might be more effective if combined with an SSRI.
    Pain RelieversTramadol (Ultram, Conzip, Qdolo) is a pain reliever that can help manage PE due to its side effect of delaying ejaculation. It should not be combined with SSRI. 

    Apart from oral medications, you can manage your PE by taking supplements such as zinc and magnesium.

    Behavioral techniques, therapies, and some exercises can also help increase the ejaculation time.

    Are you looking for exercises to manage your Premature Ejaculation? It is recommended to read this article: Exercise for Premature Ejaculation: What it is and Types.


    Premature ejaculation is a common Sexual Dysfunction in men and Assigned Males at Birth (AMAB).

    According to several studies, Sertraline for Premature Ejaculation is an effective treatment. 

    25mg, 50mg, and 100mg of dosage of Sertraline can be taken to manage PE. 

    However, it is important to know about the side effects and interactions of Sertraline before taking it for treating PE.

    It can cause nausea, dry mouth, Diarrhea, and Erectile Dysfunction. It may also cause rare side effects in individuals, such as excessive bleeding and seizures. 

    It can interact with meds such as Benadryl (Diphenhydramine) and Vyvanse (Lisdexamfetamine) and health conditions such as Hyponatremia and Glaucoma.

    Sertraline’s efficacy can be affected due to its side effects and interactions, which is why doctors may recommend alternatives to Sertraline. 

    An alternative to Sertraline may include Dapoxetine and Paroxetine.

    It would be best to consult a doctor before taking Sertraline for PE.

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  • Frequently Asked Questions

    How long does Sertraline take to show its effect on Premature Ejaculation?

    The effects of Sertraline on Premature Ejaculation may not be immediate. Individuals may experience improvement in their ejaculation time after four weeks of taking Sertraline.

    Can I take Viagra with Sertraline?

    Yes, you may take Viagra (or Sildenafil) along with Sertraline. It is generally safe to consume Viagra with Sertraline. ED medicines are more effective when taken with SSRIs. Since ED meds are not approved for PE, consult a doctor for taking ED medicines for PE.

    What are concerning side effects of Sertraline?

    You may experience some rare side effects such as Serotonin Syndrome, low sodium levels, and increased risk of bleeding.

    What if I stopped taking Sertraline for my Premature Ejaculation?

    Sertraline withdrawal can bring back the symptoms of PE. Sertraline is not a permanent cure for Premature Ejaculation.

    Can I drink alcohol while consuming Sertraline?

    No, it is not advised to drink alcohol with Sertraline. The interaction between alcohol and Sertraline can increase its side effects and lower its efficacy in treating PE.

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    Janet Fudge is a highly skilled and experienced pharmacologist who serves as a contributing writer for With a strong academic background from a premier US University and a passion for helping others, Janet has become a trusted voice in the pharmaceutical world. After completing her Doctor of Pharmacy degree, Janet embarked on a successful career in the pharmaceutical industry, working with various clients, including hospitals, retail pharmacies, and drug manufacturers. Her in-depth knowledge of pharmacology and dedication to patient-centered care has led her to excel in her field. As a writer for, Janet uses her wealth of expertise to provide readers with accurate, reliable, and up-to-date information on various topics related to medicine and healthcare. Her engaging writing style and ability to break down complex topics into easily digestible content make her a valuable resource for healthcare professionals and the general public.