What Are The Different Premature Ejaculation Medication

Premature Ejaculation (PE) can cause an individual to ejaculate too early. 

It is a common Sexual Dysfunction affecting 20-30% of men or Assigned Males at Birth (AMAB).

PE can affect a healthy relationship between partners. 

But the good news is Premature Ejaculation is treatable. There are several treatments that are effective for managing PE.

The following article will inform about Premature Ejaculation medication available for treatment.

Premature Ejaculation medication

Medicines may help in the effective treatment of Premature Ejaculation.

Medicines such as Antidepressants, PDE-5 inhibitors, and pain relievers can aid with PE.

It is important to note that these medicines are not approved for treating PE. Regardless of this, doctors may prescribe them due to their effectiveness in treating PE.

Let’s understand different medications for treating PE.


Antidepressants such as Sertraline, Paroxetine, Dapoxetine, and Citalopram are used for treating PE. 

They belong to a drug class called Selective Serotonin Reuptake Inhibitors (SSRIs).

The side effect of SSRIs is delayed ejaculation, which is why they are preferred for treating PE. 

These medicines start working within 5-10 days and can take 2-3 weeks to show their full effects.

According to a study, Sertraline can help with Premature Ejaculation. Another research mentioned the effectiveness of Sertraline in improving sexual satisfaction.

Dapoxetine has also shown its effectiveness in treating PE. It is safe and effective for PE. It was specifically developed for managing PE. 

Paroxetine is more effective than Fluoxetine (or Sertraline) and Escitalopram for treating PE.

A study stated the efficacy of Citalopram for treating Premature Ejaculation.

It is advised to consult your doctor before taking any SSRI to treat your symptoms of PE.

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  • PDE-5 inhibitors

    PDE-5 inhibitors such as Viagra(or Sildenafil) and Cialis (or Tadalafil) might help manage PE.

    According to a study, Sildenafil might be effective in treating PE. It is much more effective than Paroxetine in treating PE.

    ED medicines such as Sildenafil and Tadalafil might be effective when combined with SSRIs for treating PE.

    ED meds can also reduce the refractory period. It is the time needed to return to normal sexual activity after sex and climax. 

    Again, seeking medical advice before taking ED medications for PE is vital.

    Pain relievers

    Pain relievers such as Tramadol are used for treating pain. Tramadol might be used to treat PE because it can cause delayed ejaculation as a side effect. 

    Doctors may prescribe Tramadol when SSRIs won’t work for managing PE.

    According to a study, Tramadol might be effective for treating PE. 

    The study found that 100 men who took 100mg of Tramadol daily for 12 weeks had an improvement in their PE.

    Tramadol shouldn’t be combined with SSRIs. Consuming both the medication can result in Serotonin syndrome. 

    What are the effects of Premature Ejaculation medication

    DizzinessSource: bymuratdeniz_from_Getty_Images
    Feeling dizzy – side effect

    Taking Premature Ejaculation medicines may cause some side effects.

    It is vital to know the side effects of medicine before taking them for an effective treatment.

    The table below shows the side effects of medicines used to treat PE. 

    MedicineSide Effects
    Antidepressants (such as Sertraline, Dapoxetine, and Paroxetine)Indigestion
    Loss of appetite
    Loss of libido
    Erectile Dysfunction
    PDE-5 inhibitors (such as Sildenafil and Tadalafil)Headaches
    Heart palpitations
    Changes in vision
    Back pain
    Pain relievers  (such as Tramadol)Headache
    Dry mouth

    Are you concerned about the side effects of the medicines used for treating PE? You may want to try supplements first to manage your PE. Read this article to know more: Supplements to Delay Ejaculation: Do They Even Work

    Alternatives of Premature Ejaculation medication

    Apart from oral medications, PE can be treated with therapy, techniques, and exercises. 

    Therapies can help manage PE due to any psychological problems. It can help in reducing Performance Anxiety and increase sexual intimacy between partners.

    Mayo Clinic mentioned combining therapy with medicines can help to treat PE effectively. 

    Techniques such as start-stop strategy and squeeze techniques can also help with PE.

    Taking Dapoxetine with behavioral techniques is very effective for managing PE.

    Additionally, exercises may also help with Premature Ejaculation.

    According to a study, pelvic floor exercises can also help treat PE by strengthening the pelvic floor muscles. Weaker pelvic muscles can lead to early ejaculation. 

    Eating supplements such as zinc and magnesium can also help in delaying ejaculation. 

    It is advised to visit a doctor before trying any treatment method for your PE.

    Stop-start strategy: In the stop-start strategy, individuals stop the stimulation when they are about to ejaculate and start back when the arousal is decreased.  
    Squeeze technique:In the squeeze technique, an individual squeezes the base of the penis for about 30 seconds to delay ejaculation when they are near orgasm.

    Key Points

    There are several Premature Ejaculation medications that can help in its effective treatment.

    Dapoxetine is widely used for treating Premature Ejaculation. 

    Antidepressants such as Sertraline and Paroxetine can also be used for managing PE.

    Doctors may also prescribe ED meds such as Sildenafil and pain relievers for treating PE.

    PE medication may cause side effects such as indigestion, dizziness, and headache.

    It would be best to talk with your doctor before taking any medicine for your PE.

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  • Frequently Asked Questions

    Is it safe to take medicine for Premature Ejaculation?

    Yes, it is generally safe to take Premature Ejaculation medication. However, these medicines may cause side effects such as headache, nausea, and dizziness. It is important to consult a doctor for effective PE medicine.

    How to maintain ejaculation for 30 minutes?

    You may try exercises and masturbating before sex to maintain your ejaculation. Medicines such as Dapoxetine and Sertraline can also help in delaying ejaculation. Consult a doctor before taking medicines for your PE.

    Can Viagra delay ejaculation?

    Yes, Viagra (or Sildenafil) might help you in delaying ejaculation. Seek medical advice from a doctor. They may prescribe PDE-5 inhibitors for your PE.

    What are the other treatments for Premature Ejaculation?

    Apart from PE, medication, behavioral therapy, supplements, and exercises may help with PE. A doctor can help determine the effective PE treatment.

    Can you buy Premature Ejaculation medicines over the counter?

    No, you cannot buy PE medicines over the counter. PE medication requires a prescription from a doctor to buy them from pharmacies. A doctor can help in prescribing PE medicine suitable for you.

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    Jim Carson is a highly skilled and dedicated medical writer passionate about advancing medical practice. With years of experience in the field of medical sciences, Jim has made significant contributions to various studies aimed at improving healthcare outcomes. He currently writes for Cheapmedicineshop.com, providing expert insights and knowledge on various topics. Jim's expertise extends to various areas, including drug interactions, dosages, side effects, and best practices for medication use. In Los Angeles, Jim lives with his loving wife, children, and beloved pets. He deeply values spending time with his family and cherishes their presence. When he's not writing, Jim enjoys watching football games and staying updated with the latest sports news. Jim's writing shines through his commitment to advancing medical practice and improving healthcare outcomes. Readers can trust Jim's articles to be informative, accurate, and reliable, making him a trusted pharmaceutical information source for the website's audience.