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Glynase XL 5 is an extended-release oral anti-diabetic medication prescribed for Type 2 Diabetes mellitus in adults. Its primary ingredient is Glipizide 5 mg in an extended-release formulation, which belongs to the sulfonylurea class of anti-diabetic drugs.
USV Ltd. is the renowned manufacturer of Glynase XL 5 in India.
This medicine stimulates the pancreas to release more Insulin. This action helps lower blood glucose levels. Common side effects include Hypoglycemia (low blood sugar), weight gain, gastrointestinal disturbances, and skin reactions.
Rare, serious side effects include severe Hypoglycemia, which can further cause confusion, seizures, or loss of consciousness. This risk is notably higher in elderly patients or those with kidney or liver impairment.
Glynase XL should be stored in a cool and dry place. Keep it away from direct sunlight and moisture. Before starting treatment, inform the doctor about all existing medical conditions and medications.
This medicine is not suitable for patients with Type 1 Diabetes, Diabetic Ketoacidosis, severe kidney or liver disease, or a known allergy to sulfonylureas.
Glynase XL 5 stimulates Insulin secretion from the pancreatic beta cells. The extended-release formulation provides a gradual, controlled release of Glipizide throughout the day, resulting in sustained blood glucose control while lowering the risk of Hypoglycemic episodes.
Key benefits of Glynase XL include:
It is crucial to note that Glynase XL should be used as part of a comprehensive Diabetes management plan that involves regular physical activity, appropriate dietary modifications, and routine blood glucose monitoring.
Glynase XL is a prescription medication that should be taken as per your doctor's instructions. Here are the general guidelines:
The strengths and substitutes available for Glynase are:
| $0.90/10 tablets | |
| $0.50/10 tablets |
Glynase XL 5 is generally well-tolerated. However, it may cause side effects, including:
These adverse effects generally do not require medical consultation unless severe or persistent. Hypoglycemia is the most common side effect and may present as sweating, dizziness, trembling, hunger, confusion, or headache. Always carry a source of fast-acting sugar to treat low blood sugar episodes.
Liver disease
Glynase XL should be used with caution in patients with mild to moderate liver impairment, as the liver is involved in the metabolism of Glipizide. It is contraindicated in severe liver disease due to the increased risk of Hypoglycemia. Regular liver function monitoring is recommended before and during treatment.
Kidney impairment
Use with extreme caution in patients with mild to moderate kidney impairment. Glynase XL is not recommended for patients with severe kidney disease as reduced clearance can lead to prolonged Hypoglycemia. Regular kidney function monitoring is essential, and alternative Diabetes medications should be considered for these patients.
Pregnant and breastfeeding women
Glynase XL is not recommended during pregnancy as sulfonylureas can cross the placenta and cause fetal Hypoglycemia. Insulin is the preferred treatment for managing Diabetes during pregnancy. This medication should also be avoided during breastfeeding as Glipizide can pass into breast milk and potentially cause Hypoglycemia in the nursing infant.
Avoid
Alcohol and certain medications (like NSAIDs, Sulfonamides, beta-blockers, and MAO inhibitors) can increase the risk of Hypoglycemia with Glynase XL. To help prevent low blood sugar, avoid alcohol, maintain regular meals, and inform your doctor about all other medicines you take.
Glynase XL 5 provides extended-release of medication throughout the day, allowing once-daily dosing and more stable blood glucose control. Regular Glipizide requires multiple daily doses and may cause more pronounced blood sugar fluctuations.
Yes, Glynase XL is often prescribed alongside Metformin when Metformin alone doesn't provide adequate blood glucose control. This combination targets different aspects of glucose regulation for improved Diabetes management.
Immediately consume 15-20 grams of fast-acting carbohydrates such as glucose tablets, fruit juice, or honey. Recheck blood sugar after 15 minutes. If still low, repeat. Seek medical attention for severe or persistent Hypoglycemia.
Glynase XL 5 begins lowering blood sugar within 1-2 hours after taking it. Maximum effects are typically seen within 4-8 hours, but the extended-release formulation provides glucose control throughout 24 hours.
Weight gain is a possible side effect of Glynase XL and other sulfonylureas. This occurs because improved glucose control allows your body to utilize and store calories more effectively. Regular exercise and dietary management can minimize weight gain.
