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Peroclin 5 gel is a topical acne treatment for moderate to severe acne vulgaris in adolescents and adults. Its primary ingredients are Benzoyl Peroxide (5% w/w) and Clindamycin (1% w/w), a powerful combination that addresses multiple factors of acne pathogenesis.
Ajanta Pharma Ltd is the leading manufacturer of Peroclin 5 gel. This dual-action formulation reduces acne-causing bacteria, decreases inflammation, and removes excess oil and dead skin cells that clog pores. Side effects of Peroclin gel may include dryness, redness, peeling, and occasional skin irritation.
These side effects are mild and transient, typically decreasing with continued use. The gel is applied directly to affected areas of the skin once or twice daily after cleansing, with visible improvement normally seen within 2-4 weeks of consistent use.
This gel should be stored in a cool, dry place away from direct sunlight and heat sources, ideally at room temperature (20-25°C or 68-77°F). It is essential to keep the gel tightly sealed in its original container to prevent contamination and to ensure its efficacy.
Avoid storing it in damp areas such as bathrooms, and keep it out of reach of children and pets. Additionally, check the expiration date before use, and do not use the gel if it appears discolored or if the packaging is damaged. Always follow the manufacturer's instructions regarding usage and disposal to ensure safety and effectiveness.
Peroclin 5 gel works through a synergistic dual mechanism. Benzoyl peroxide acts as a powerful oxidizing agent that releases oxygen-free radicals, which destroy P. acnes bacteria by breaking down bacterial proteins.
It also has mild keratolytic and comedolytic properties. Clindamycin phosphate is an antibiotic that inhibits bacterial protein synthesis, effectively targeting inflammatory acne lesions.
Peroclin provides multiple therapeutic benefits:
It is crucial to note that consistent use as directed is essential for optimal results, and sun protection should be used while undergoing treatment.
Peroclin is a prescription medication that should be used as per your doctor's instructions. Here are the general guidelines:
Currently, no strength alternatives are available for Peroclin gel. However, the following substitutes are available:
| $3.05 / tube |
Peroclin is generally well-tolerated when used as directed. However, it may cause side effects, including:
These adverse effects typically decrease after the first few weeks of treatment as your skin adjusts to the medication. If dryness is bothersome, use moisturizer and sunscreen to prevent sunburn.
Liver disease
Peroclin gel is applied topically with minimal systemic absorption, so liver disease generally does not affect its use. However, patients with severe liver impairment should inform their physician, as higher systemic absorption of clindamycin could potentially occur through damaged skin.
Kidney impairment
Patients with kidney disease do not require specific dosage adjustments when using Peroclin gel—the topical application results in minimal systemic absorption. However, inform your healthcare provider about any kidney conditions before starting treatment.
Pregnant and breastfeeding women
Peroclin gel should be used during pregnancy only if needed. Limited data exist on topical benzoyl peroxide and clindamycin safety during pregnancy. Clindamycin may pass into breast milk when taken orally, but the risk is likely lower with topical application. Consult your healthcare provider regarding risks and benefits if pregnant or breastfeeding.
Avoid
Avoid using Peroclin gel concurrently with products containing retinoids, alpha hydroxy acids, or other potentially irritating ingredients, as this may increase skin irritation. Limit sun exposure and use sunscreen (SPF 30+) while using this medication. Avoid contact with colored fabrics, as benzoyl peroxide has bleaching properties that can discolor clothing, towels, and bedding.
Peroclin 5% gel should not be used concurrently with other topical acne treatments unless specifically directed by your dermatologist. Combined use with retinoids or exfoliants may increase irritation. Allow at least 1-2 hours between different topical treatments.
Most patients begin to see improvement within 2-4 weeks of regular use. Significant results typically require 6-8 weeks of consistent application. To prevent recurrence, continue using the medication as prescribed even after acne improves.
Peroclin 5 gel is most effective for inflammatory acne (red, painful bumps) and mild to moderate papules and pustules. It may be less effective for severe nodular or cystic acne. Your dermatologist can recommend additional treatments if needed.
Peroclin 5% gel may temporarily cause redness at application sites but typically doesn't cause permanent discoloration. However, using the gel on sunburned skin or without adequate sun protection may result in post-inflammatory hyperpigmentation, especially in darker skin tones.
To prevent recurrence, many dermatologists recommend continuing Peroclin 5% gel for several months after acne clears. Your doctor may eventually suggest a maintenance regimen, possibly with reduced frequency of application or alternative treatments.
