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Pramipex 0.125 mg tablet is a dopamine agonist medication primarily used to treat Parkinson's disease and Restless Legs Syndrome (RLS) in adults. Its active ingredient, Pramipexole (0.125 mg), belongs to the non-ergoline dopamine agonist class of drugs.
Sun Pharmaceutical Industries Ltd manufactures Pramipex. It works by stimulating dopamine receptors in the brain, helping to improve motor function and reduce tremors.
This medication may cause side effects such as drowsiness, dizziness, nausea, and, in some cases, impulse control disorders. It should be stored at room temperature, away from moisture and light.
Individuals should exercise caution when driving or using machinery, as Pramipex can cause sudden sleep episodes. The medication should be taken exactly as prescribed, with a gradual increase in dosage to minimize side effects.
The medicine can interact with some sleep medications and antihistamines. To ensure safety, it is vital to discuss your current medicines and medical history with a medical expert before using Pramipexole.
Pramipex tablet works by mimicking the action of dopamine in the brain. Since Parkinson's disease and Restless Legs Syndrome are associated with dopamine deficiency, Pramipexole binds to dopamine D2 and D3 receptors, particularly in the striatum and substantia nigra regions of the brain.
Pramipex offers dual therapeutic benefits:
It is crucial to note that while Pramipex provides symptomatic relief, it does not cure the underlying condition or stop disease progression.
Pramipex is a prescription medication that should be taken as per your doctor's instructions. Here are the general guidelines:
The strengths and substitutes available for Pramipex are:
| $2.40 / 10 Tablet | |
| $4.10 / 10 Tablet | |
| $7.10 / 10 Tablet | |
| $14.20 / 10 Tablet |
Pramipex is generally well-tolerated when taken as prescribed. However, it may cause side effects, including:
These adverse effects typically subside as your body adjusts to the medication, but consult your doctor if they persist or worsen.
Liver disease
People with liver impairment may require dosage adjustments as Pramipex is partially metabolized in the liver. Regular liver function monitoring is recommended. Those with severe liver disease should use Pramipex with caution and under close medical supervision.
Kidney impairment
Pramipex requires careful dosing in patients with kidney impairment as it is primarily eliminated via the kidneys. Dosage reductions are necessary for moderate to severe kidney disease. Regular kidney function tests are advised during treatment.
Pregnant and breastfeeding women
Pramipex is not recommended during pregnancy unless clearly necessary. Animal studies have depicted a possibility of adverse effects, but human data is limited. The medicine may pass into breast milk, so breastfeeding is not advised while taking Pramipex. Consult your doctor for appropriate alternatives.
Avoid
Alcohol consumption should be avoided as it may increase drowsiness and dizziness. Grapefruit juice may interfere with Pramipex metabolism. Use caution with other CNS depressants like sedatives, antipsychotics, and antidepressants, as they may enhance the sedative effects of Pramipex.
Yes, Pramipex can be used with other Parkinson's medications like Levodopa. However, dose adjustments may be necessary as Pramipex may enhance levodopa's effects and potentially increase dyskinesia. Always consult your doctor before combining treatments.
Monitor for unusual urges or behaviors, as Pramipex may cause impulse control disorders. Stand up slowly to prevent dizziness. Avoid works that need concentration until you know how the medicine affects you, as it can cause sudden sleep episodes.
Some patients may notice improvement within days, but full therapeutic benefits typically develop over several weeks. Restless Legs Syndrome symptoms often respond faster than Parkinson's symptoms. Patience and consistent use are essential for optimal results.
Yes, abrupt discontinuation of Pramipex may lead to withdrawal symptoms or worsening of Parkinson's symptoms. These may include anxiety, depression, fatigue, pain, and difficulty sleeping. Always taper off gradually under medical supervision.
Caution is advised, as Pramipex can cause sudden sleep episodes without warning. Some patients experience drowsiness or dizziness that impairs reaction time. Avoid driving or operating machinery until you understand how the medication affects you.
