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Promet 10 mg is a prescription medication containing Metoclopramide, a dopamine receptor antagonist and prokinetic agent. It primarily treats gastrointestinal disorders characterized by impaired motility. This medication belongs to a class of drugs known as antiemetics and prokinetics that work on both the central nervous system and the gastrointestinal tract to alleviate nausea, vomiting, and motility disorders.
Lupin Ltd is the leading manufacturer of Promet 10 tablets, ensuring consistent quality and efficacy in each tablet. Metoclopramide exerts its therapeutic effect through two primary mechanisms. Centrally, it blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) of the brain to prevent nausea and vomiting.
Peripherally, it enhances the response to acetylcholine in the upper gastrointestinal tract. This accelerates gastric emptying and intestinal transit while increasing lower esophageal sphincter tone.
Promet 10 is most commonly prescribed for conditions such as diabetic gastroparesis (delayed stomach emptying) and Gastroesophageal Reflux Disease (GERD). It also prevents nausea and vomiting associated with chemotherapy, radiation therapy, or surgical procedures. It is also used as a diagnostic aid in certain radiological examinations of the gastrointestinal tract, where it facilitates the passage of barium through the digestive system and improves visualization.
Common side effects of Promet 10 may include drowsiness, fatigue, restlessness, and diarrhea. More serious side effects may include Extrapyramidal Symptoms (EPS) such as dystonic reactions, parkinsonian symptoms, akathisia, and tardive dyskinesia (potentially irreversible involuntary movements) with prolonged use.
Promet 10 mg offers dual action on the central nervous system and the gastrointestinal tract. It works by blocking dopamine receptors in the chemoreceptor trigger zone (CTZ) of the brain while enhancing acetylcholine's effect on the digestive tract, effectively addressing multiple symptoms simultaneously.
The primary benefits include:
It is crucial to note that Promet 10 is generally recommended for short-term use (typically not exceeding 12 weeks) due to the risk of developing tardive dyskinesia with prolonged use, particularly in elderly patients.
Promet 10 is a prescription medication that should be taken per your doctor's instructions. Here are the general guidelines:
Currently, there are no strength alternatives for Promet. However, the following substitutes are available:
| $0.6 / 10 tablets | |
| $0.6 / 10 tablets |
Promet 10 is generally effective when used properly. However, it may cause side effects, including:
These adverse effects vary in severity and occurrence. More serious side effects include tardive dyskinesia and neuroleptic malignant syndrome, which require immediate medical attention.
Liver disease
Patients with liver disease should use Promet with caution as hepatic impairment may alter drug metabolism and clearance. While specific dosage adjustments are not typically required for mild to moderate liver disease, patients with severe hepatic dysfunction should be monitored closely for increased sensitivity to the drug's effects.
Kidney impairment
Dosage reduction is necessary for patients with moderate to severe renal impairment, as Metoclopramide is primarily eliminated through the kidneys. For patients with creatinine clearance below 40 mL/minute, the dose should generally be reduced by 50%. Regular renal function monitoring is recommended during treatment.
Pregnant and breastfeeding women
Promet is classified as FDA Pregnancy Category B, indicating that animal studies have not shown risk to the fetus, but there are no adequate controlled studies in pregnant women. It should be used only during pregnancy if prescribed when needed, and the benefits outweigh the risks. Metoclopramide is excreted in breast milk and may affect a nursing infant, so caution is advised during breastfeeding.
Avoid
Avoid alcohol as it may impair coordination. Do not administer medications that cause drowsiness, including antihistamines, sleep aids, and certain antidepressants or antipsychotic medications, which may increase the risk of extrapyramidal symptoms. MAO inhibitors should be discontinued at least 2 weeks before starting Promet
Promet 10 blocks dopamine receptors in the brain's chemoreceptor trigger zone (CTZ), which controls the vomiting reflex. It also accelerates gastric emptying, reducing stomach distension that can trigger nausea. These combined central and peripheral actions make it effective for various types of nausea and vomiting.
Take Promet 30 minutes before meals and bedtime with water for optimal results. This timing allows the medication to accelerate gastric emptying during meals. Consistent timing is vital for maintaining therapeutic blood levels.
Promet 10 begins to work within 30-60 minutes after oral administration. For acute nausea and vomiting, many patients experience relief within the first hour. The effects typically last 1-2 hours after a single dose, so multiple daily doses are usually prescribed.
Promet 10 is generally not recommended for long-term use (beyond 12 weeks) due to the risk of developing tardive dyskinesia, a potentially irreversible movement disorder. After consulting with your doctor, intermittent therapy or alternative medications should be considered for chronic conditions requiring prolonged treatment.
If you develop involuntary movements of the face, tongue, or limbs, stop taking Promet 10 immediately and contact your healthcare provider. These symptoms may indicate tardive dyskinesia or other extrapyramidal effects. Prompt discontinuation may prevent these symptoms from becoming permanent.
