Aplevant 1.5mg Pre-filled Pen (0.5ml Each)

What is Aplevant 1.5

Aplevant 1.5 is an injectable antidiabetic medication used to treat Type 2 Diabetes in adults. Its primary ingredient is Dulaglutide (1.5 mg), which is a glucagon-like peptide-1 (GLP-1) receptor agonist. Lupin Ltd is the renowned manufacturer of Aplevant 1.5 mg.

This medicine regulates blood sugar levels by mimicking natural GLP-1 hormone functions in the body. Dulaglutide stimulates Insulin secretion when blood glucose is elevated, suppresses Glucagon release, and slows gastric emptying.

Unlike natural GLP-1, which works for minutes, Dulaglutide provides week-long glucose control with once-weekly injections. Aplevant also reduces cardiovascular risks in Diabetic patients with established heart disease.

It is administered as a subcutaneous injection using a pre-filled pen device. It can be used alone or combined with other antidiabetic medications like Metformin, Sulfonylureas, or Insulin. Aplevant provides additional benefits, including weight loss support and appetite reduction.

The once-weekly dosing improves treatment adherence compared to daily medications.

Common Aplevant side effects include nausea, diarrhea, vomiting, abdominal pain, and decreased appetite. These effects usually diminish over time as the body adjusts.

Store injection pens in the refrigerator between 2°C and 8°C, protected from light. Never freeze or shake the pen. Always follow the prescribed dosage and injection techniques. Regular blood sugar monitoring and periodic kidney function tests are essential during treatment to ensure optimal safety and effectiveness.

What are the benefits of Aplevant 1.5

Aplevant 1.5 reduces fasting glucose concentrations and postprandial glucose levels in Type 2 Diabetes patients through GLP-1 receptor agonism. It stimulates Insulin secretion when blood glucose is high, suppressing glucagon release to prevent excessive glucose production by the liver. This effect slows gastric emptying.

Key benefits include effective HbA1c reduction, convenient once-weekly dosing, and significant weight loss support. The medication also works by slowing food movement through the stomach, helping control appetite and portion sizes.

Additional cardiovascular protection benefits include reduced risk of major cardiac events in patients with established heart disease. It is crucial to note that Aplevant should be used alongside a good diet and exercise for optimal Diabetes management results.

How to take Aplevant 1.5

Aplevant 1.5 is a prescription medication that should be taken as per your doctor's instructions. Here are the general guidelines:

• Inject Aplevant 1.5 mg once weekly on the same day each week.
• Administer subcutaneously in the thigh, abdomen, or upper arm using the pre-filled pen.
• It can be taken with or without food at any time of day.
• Do not exceed 1 injection per week.

Strengths and substitutes

The strengths and substitutes available for Aplevant 1.5 at Cheap Medicine Shop are:

View all substitutes

What are the side effects of Aplevant 1.5

Aplevant 1.5 is generally well-tolerated. However, it may cause side effects, including:

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Decreased appetite
• Injection site reactions

These effects typically do not require medical consultation and disappear as your body adjusts to treatment. If they worsen, seek medical help immediately.

Safety Advice

Liver disease

Aplevant can be used in patients with mild to moderate liver impairment without dose adjustments. However, patients with severe liver disease should use this medication with caution. Regular liver function monitoring may be required. Discuss existing liver conditions with your healthcare provider before starting treatment.

Kidney impairment

Aplevant's effectiveness and safety are maintained in patients with mild to moderate kidney disease. Patients with severe kidney impairment should use it with caution. Regular kidney function monitoring is recommended. Dose adjustments are generally not required for mild kidney conditions.

Pregnant and breastfeeding women

Aplevant is not recommended during pregnancy as safety data is limited, and it may affect fetal development. Women planning pregnancy should discuss alternative Diabetes treatments with their doctor. Breastfeeding mothers should avoid it as it is unknown if Dulaglutide passes into breast milk.

Avoid

Avoid alcohol consumption as it may increase the possibility of low blood sugar and gastrointestinal side effects. Do not combine with other GLP-1 agonists or medications that significantly delay gastric emptying. Avoid activities requiring alertness if experiencing severe nausea or dizziness after injection.