Glura M 500 Tablet

What is Glura M 500

Glura M 500 combines two powerful anti-diabetic agents for Type 2 Diabetes management in adults. Each tablet contains FDA-approved Sitagliptin 50 mg and Metformin 500 mg in a single convenient formulation.

This dual-action formula addresses multiple aspects of glucose control simultaneously through different mechanisms. Sitagliptin belongs to the Dipeptidyl Peptidase-4 (DPP-4) inhibitor class, while Metformin represents the biguanide medication category.

Eris Lifesciences Ltd manufactures this innovative combination therapy with proven clinical efficacy and safety. The tablet effectively targets both Insulin resistance and inadequate Insulin production pathways.

Sitagliptin enhances natural Insulin release when blood glucose levels rise above normal ranges. Metformin reduces excessive liver glucose production and significantly improves cellular glucose uptake efficiency.

Common side effects during initial treatment include mild gastrointestinal upset, occasional nausea, and temporary diarrhea. Take tablets with meals to minimize stomach irritation and improve tolerability.

Store in cool, dry places away from direct sunlight and moisture. Regular kidney function monitoring remains essential during long-term treatment. Never crush or chew tablets, as this affects controlled medication release mechanisms.

What are the benefits of Glura M 500

Glura M 500 provides comprehensive glucose control through complementary mechanisms targeting different Diabetes pathways. Sitagliptin increases incretin hormone activity, which stimulates Insulin release only when glucose levels are elevated above normal.

This glucose-dependent action significantly reduces the dangerous Hypoglycemia risk during treatment. Key therapeutic advantages include:

• Improves both fasting and post-meal glucose levels effectively throughout the day.
• Supports natural pancreatic Insulin production without forcing exhausted pancreatic beta cells.
• Reduces hepatic glucose output during overnight fasting periods significantly.
• Minimizes weight gain commonly associated with other anti-diabetic medication classes.

The Metformin component enhances peripheral Insulin sensitivity and decreases intestinal glucose absorption effectively. The combination approach simultaneously addresses multiple pathways involved in Type 2 Diabetes progression. Patients often achieve superior HbA1c reduction compared to single-agent therapy approaches.

How to take Glura M 500

Glura M 500 requires a medical prescription and regular monitoring. Follow your physician's specific dosing recommendations:

• Take twice daily with morning and evening meals.
• Swallow tablets whole with adequate water.
• Maintain consistent timing for optimal blood glucose control.
• Do not exceed prescribed daily dosage limits.

Strengths and substitutes

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What are the side effects of Glura M 500

Glura M 500 demonstrates good tolerability in most patients. Potential side effects include:

• Stomach upset
• Mild nausea
• Diarrhea
• Metallic taste sensation
• Headache
• Dizziness

These symptoms usually improve as your body adjusts to treatment.

Safety Advice

Liver disease

Liver impairment can affect Metformin metabolism and increase the possibility of Lactic Acidosis. Regular liver function monitoring is crucial during treatment. Based on hepatic enzyme levels, dose adjustments may be necessary. Consult a doctor before use.

Kidney impairment

Kidney dysfunction significantly increases the risk of Metformin-related Lactic Acidosis. Treatment is contraindicated in severe cases. Regular kidney function assessment ensures safe continuation. Consult a doctor before use.

Pregnant and breastfeeding women

Glura M 500 is not recommended during pregnancy as safety data remains limited. Insulin therapy is preferred for gestational glucose control. Avoid it during breastfeeding due to unknown effects on infants.

Avoid

Excessive alcohol consumption increases the possibility of Lactic Acidosis when combined with Metformin. Contrast dye procedures require temporary medication discontinuation. Avoid during severe illness or dehydration episodes.