Janumet 50 Mg/1000 Mg Tablet

What is Janumet 50/1000

Janumet 50/1000 is a combination anti-diabetic medication used to treat Type 2 Diabetes Mellitus in adults when diet and exercise alone do not provide adequate blood glucose control. Its primary ingredients are Sitagliptin (50 mg) and Metformin Hydrochloride (1000 mg), which work through complementary mechanisms to lower blood sugar levels.

Merck Co. is the leading manufacturer of Janumet. This oral medication helps improve glycemic control by enhancing insulin secretion, reducing liver glucose production, and increasing cellular sensitivity to insulin.

Common side effects include gastrointestinal disturbances, upper respiratory tract infections, and Hypoglycemia when used with certain other Diabetes medications. Janumet should be stored at room temperature (68-77°F) and protected from moisture and light.

It should be taken with meals to minimize gastrointestinal side effects, and regular monitoring of kidney function is required during treatment.

What are the benefits of Janumet 50/1000

Janumet 50/1000 combines two anti-diabetic medications with complementary mechanisms of action. Sitagliptin inhibits the DPP-4 enzyme, preventing the breakdown of incretin hormones that stimulate insulin release and suppress glucagon secretion.

Metformin reduces hepatic glucose production, decreases intestinal glucose absorption, and improves insulin sensitivity in peripheral tissues.

Benefits of Janumet 50/1000 include:

• Effective reduction in fasting and post-meal blood glucose levels.
• Improvement in HbA1c levels without significant weight gain.
• Convenient twice-daily dosing that combines two medications.
• Lower risk of Hypoglycemia compared to sulfonylurea-based therapies.

It is crucial to note that Janumet is an adjunct to diet and exercise, not a substitute for lifestyle modifications essential for Diabetes management.

How to take Janumet 50/1000

Janumet 50 mg/1000 mg is a prescription medication that should be taken per your doctor's instructions. Here are the general guidelines:

• Take Janumet 50/1000 twice daily with meals to reduce gastrointestinal side effects.
• Swallow tablets whole with a full glass of water; do not crush, split, or chew them.
• Maintain consistent timing of doses to optimize blood glucose control. Do not exceed the recommended dosage of two tablets (100 mg Sitagliptin/2000 mg Metformin) per day.

Strengths and substitutes

The strengths and substitutes available for Janumet are:

View all substitutes

What are the side effects of Janumet 50/1000

Janumet 50/1000 is generally well-tolerated. However, it may cause side effects, including:

• Gastrointestinal disturbances (nausea, vomiting, diarrhea, abdominal discomfort)
• Metallic taste in the mouth
• Upper respiratory tract infection
• Headache

These adverse effects typically decrease over time as your body adjusts to the medication. Gastrointestinal symptoms can be minimized by taking Janumet with food and beginning with a lower dose when initiating therapy.

Safety Advice

Liver disease

Janumet should be used with caution in people with liver disease as impaired hepatic function may increase the possibility of lactic acidosis, a rare but serious side effect. Regular liver function tests are recommended. Janumet is contraindicated in patients with severe hepatic impairment.

Kidney impairment

Janumet is contraindicated in patients with moderate to severe kidney impairment. Kidney function should be assessed before treatment and regularly thereafter. Based on kidney function, dose adjustments or alternative medications may be necessary.

Pregnant and breastfeeding women

Janumet is not recommended during pregnancy or breastfeeding. Limited data exist on Sitagliptin use during pregnancy, while Metformin may be considered in some cases. Women planning pregnancy should discuss alternative Diabetes management strategies with their healthcare provider. Insulin is typically the preferred treatment for Diabetes during pregnancy.

Avoid

Alcohol consumption should be avoided while taking Janumet. Use caution with medications that may affect kidney function, such as NSAIDs, certain antibiotics, and diuretics, as they may increase Metformin-associated risks.