Oxiplat 100 Mg Injection

What is Oxiplat 100 mg Injection

Oxiplat 100 mg Injection is a chemotherapy medication used to treat various types of Cancer, primarily Colorectal Cancer, in adult patients. Its primary ingredient is Oxaliplatin (100mg), a platinum-based antineoplastic agent. This powerful medication works by forming cross-links in DNA, interfering with DNA replication and transcription, ultimately leading to cell death, particularly in rapidly dividing cancer cells.

Sun Pharmaceutical Industries Ltd is the renowned manufacturer of Oxiplat 100 mg, ensuring high-quality production standards for this critical Cancer treatment. Oxiplat 100 is typically administered as part of combination chemotherapy regimens, most commonly with Fluorouracil (5-FU) and Leucovorin in the FOLFOX protocol

It is primarily used in the treatment of advanced Colorectal Cancer and as adjuvant therapy following the surgical removal of primary tumors. The medication is delivered through intravenous infusion in a controlled healthcare setting under the supervision of oncologists.

What are the benefits of Oxiplat 100 mg Injection

Oxiplat 100 Injection contains Oxyliplatin, a platinum compound that forms inter- and intra-strand cross-links in DNA, preventing DNA replication and transcription. This leads to cell cycle arrest and programmed cell death (apoptosis), particularly effective against rapidly dividing cancer cells. Unlike other platinum compounds, Oxyliplatin has a unique diamino cyclohexane (DACH) carrier ligand that may help overcome platinum resistance.

Benefits include:

• Effectively targets and destroys Colorectal Cancer cells.
• It improves survival rates when used as adjuvant therapy after colorectal cancer surgery.
• Enhances effectiveness when used in combination with other chemotherapy agents.
• It may be effective in some cases where cancer has shown resistance to other platinum-based treatments.
• It can help shrink tumors before surgery (neoadjuvant therapy).

It is crucial to note that healthcare professionals must administer Oxiplat in a controlled setting with appropriate monitoring for side effects.

How to use Oxiplat 100 mg Injection

Oxiplat is a prescription medication that should be taken as per your doctor's instructions. Do not self-administer.

Here are the general guidelines:

• Oxiplat 100 is administered as an intravenous infusion over 2-6 hours.
• Typically given once every 2-3 weeks as part of a treatment cycle. Often combined with other chemotherapy medications like 5-FU and Leucovorin.
• Pre-medications may be given to prevent nausea and allergic reactions.
• Treatment cycles usually continue for 6 months or as determined by your oncologist.

Strength and substitutes

The strengths and substitutes available for Oxiplat are:

View all substitutes

What are the side effects of Oxiplat 100 mg Injection

Oxiplat is a potent chemotherapy medication. It may cause side effects, including:

• Peripheral neuropathy (tingling, numbness in hands/feet, sensitivity to cold)
• Nausea, vomiting, and diarrhea
• Fatigue and weakness
• Decreased blood counts (increased risk of infection, bleeding, anemia)

These adverse effects often require medical management and may necessitate dose adjustments. Your healthcare team will monitor you and provide supportive care to manage side effects.

Safety Advice

Liver disease

Oxiplat requires careful monitoring in patients with liver disease. Mild to moderate liver impairment may require dose adjustments. Liver function tests should be performed before each treatment cycle. In severe liver impairment, alternative treatments may be considered.

Kidney impairment

Patients with kidney disease require dose adjustments for Oxiplat, as it is primarily eliminated through the kidneys. Regular monitoring of kidney function is essential. Your doctor may reduce the dose or consider alternative treatments in severe kidney impairment.

Pregnant and breastfeeding women

Oxiplat is contraindicated during pregnancy as it can cause fetal harm. Effective contraception must be used during treatment and for at least 6 months after the last dose. Breastfeeding is not recommended during treatment and for several months afterward, as the drug may pass into breast milk and harm the infant.

Avoid

Avoid cold foods, drinks, and exposure to cold temperatures during treatment and for several days after infusion, as this can trigger or worsen neuropathy symptoms. Avoid contact with those who have infections or have recently received live vaccines. Avoid alcohol, as it may increase liver toxicity. Certain medications may interact with Oxiplat 100, so inform your doctor about all your medications.