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Peg Grafeel 6 mg injection is a prescription medicine used to prevent infections in Cancer patients receiving chemotherapy. Its primary ingredient is Pegfilgrastim, a long-acting Granulocyte Colony-stimulating Factor (G-CSF). Dr Reddy's Laboratories Ltd manufactures Peg Grafeel 6 mg.
This medication stimulates neutrophil production in bone marrow, helping prevent Febrile Neutropenia (low white blood cell count with fever). The pegylated formulation provides an extended duration of action compared to regular filgrastim. Each pre-filled syringe contains 6 mg in a 0.6 ml solution.
Common Peg Grafeel side effects include bone pain, muscle aches, headache, and injection site reactions. Serious side effects may include splenic rupture or acute respiratory distress syndrome.
Store in the refrigerator at 2-8°C and protect from light. Allow to reach room temperature before injection. Do not use it without a doctor’s consultation, especially if you have liver problems or are pregnant.
Peg Grafeel 6 mg injection works by binding to G-CSF receptors on neutrophil precursor cells in bone marrow. This stimulates proliferation, differentiation, and activation of neutrophils (infection-fighting white blood cells). The pegylation process extends the medication's half-life, requiring less frequent dosing.
Key benefits include:
It is crucial to note that this medication should not be given within 14 days before chemotherapy or within 24 hours after chemotherapy.
Peg Grafeel 6 mg is a prescription medication that should be administered as per your doctor's instructions. Here are the general guidelines:
The strengths and substitutes available at Cheap Medicine Shop are:
| $196.88/injection | |
| $107.42/injection |
Peg Grafeel 6 mg is generally well-tolerated in most patients. However, it may cause side effects, including:
Most of these adverse effects typically do not require medical consultation and disappear as your body adjusts. However, if they persist, seek medical help.
Liver disease
Patients with liver disease should use Peg Grafeel with caution as hepatic impairment may affect drug metabolism. Regular monitoring of liver function tests is needed during treatment. Dose adjustments are generally not required for mild liver dysfunction.
Kidney impairment
Peg Grafeel can be used safely in patients with kidney impairment as renal elimination is minimal. However, monitoring of kidney function is advisable in patients with severe renal disease. No dose adjustment is typically necessary for kidney dysfunction.
Pregnant and breastfeeding women
Pegfilgrastim injection should be used during pregnancy only if the benefits outweigh the potential risks to the fetus. It is unknown whether Pegfilgrastim is excreted in human breast milk. Consult your oncologist before use during pregnancy or breastfeeding.
Avoid
Avoid live vaccines during treatment as an immune response may be altered. Do not take medications that suppress bone marrow function. Avoid contact with people who have infections. Do not donate blood or blood products during treatment.
Peg Grafeel 6 mg should be administered 24 hours after your chemotherapy session ends. Then it should not be taken within 14 days before your next cycle begins. This timing ensures optimal neutrophil recovery while avoiding interference with chemotherapy effectiveness.
Due to its long-acting pegylated formulation, Peg Grafeel 6 mg provides neutrophil support for approximately 14-21 days after injection. Peak neutrophil levels typically occur 3-5 days after administration, then gradually return to baseline before the next chemotherapy cycle.
Yes, after proper training from your healthcare team, you can self-administer subcutaneous injections at home. Follow sterile technique, rotate injection sites, and dispose of needles safely. Never share needles or reuse syringes.
Bone pain is a common side effect that usually resolves within a few days. Over-the-counter pain relievers like Acetaminophen may help. Contact your doctor if pain is severe or persistent, as prescription pain medication may be necessary.
Peg Grafeel 6 mg is generally safe with most Cancer treatments when used as directed. However, inform your oncologist about all medications, supplements, and treatments you're receiving. Some drug interactions may require timing adjustments or monitoring changes.
