Peroclin 5% Gel

What is Peroclin 5 gel

Peroclin 5 gel is a topical acne treatment for moderate to severe acne vulgaris in adolescents and adults. Its primary ingredients are Benzoyl Peroxide (5% w/w) and Clindamycin (1% w/w), a powerful combination that addresses multiple factors of acne pathogenesis.

Ajanta Pharma Ltd is the leading manufacturer of Peroclin 5 gel. This dual-action formulation reduces acne-causing bacteria, decreases inflammation, and removes excess oil and dead skin cells that clog pores. Side effects of Peroclin gel may include dryness, redness, peeling, and occasional skin irritation.

These side effects are mild and transient, typically decreasing with continued use. The gel is applied directly to affected areas of the skin once or twice daily after cleansing, with visible improvement normally seen within 2-4 weeks of consistent use.

This gel should be stored in a cool, dry place away from direct sunlight and heat sources, ideally at room temperature (20-25°C or 68-77°F). It is essential to keep the gel tightly sealed in its original container to prevent contamination and to ensure its efficacy.

Avoid storing it in damp areas such as bathrooms, and keep it out of reach of children and pets. Additionally, check the expiration date before use, and do not use the gel if it appears discolored or if the packaging is damaged. Always follow the manufacturer's instructions regarding usage and disposal to ensure safety and effectiveness.

What are the benefits of Peroclin 5 gel

Peroclin 5 gel works through a synergistic dual mechanism. Benzoyl peroxide acts as a powerful oxidizing agent that releases oxygen-free radicals, which destroy P. acnes bacteria by breaking down bacterial proteins.

It also has mild keratolytic and comedolytic properties. Clindamycin phosphate is an antibiotic that inhibits bacterial protein synthesis, effectively targeting inflammatory acne lesions.

Peroclin provides multiple therapeutic benefits:

• Reduces acne-causing bacteria (P. acnes) through dual antimicrobial action
• Decreases inflammation associated with acne pustules and papules
• It helps prevent bacterial resistance that can occur with antibiotic monotherapy
• Unclogs pores by promoting the shedding of dead skin cells
• Controls sebum production to reduce oiliness

It is crucial to note that consistent use as directed is essential for optimal results, and sun protection should be used while undergoing treatment.

How to use Peroclin 5 gel

Peroclin is a prescription medication that should be used as per your doctor's instructions. Here are the general guidelines:

• Apply Peroclin to affected areas once or twice daily after thoroughly cleansing and drying the skin.
• Use a thin layer of gel; applying more will not increase effectiveness but may increase irritation.
• Avoid contact with eyes, mouth, nostrils, mucous membranes, and cuts or broken skin. Wash hands thoroughly after application to prevent transfer to sensitive areas.
• Do not apply other topical products containing alcohol or astringents simultaneously.

Strength and substitutes

Currently, no strength alternatives are available for Peroclin gel. However, the following substitutes are available:

What are the side effects of Peroclin 5 gel

Peroclin is generally well-tolerated when used as directed. However, it may cause side effects, including:

• Skin dryness, redness, and peeling
• Temporary stinging or burning sensation
• Contact dermatitis or allergic reactions
• Photosensitivity (increased sensitivity to sunlight)
• Bleaching of hair, clothing, or bedding due to benzoyl peroxide

These adverse effects typically decrease after the first few weeks of treatment as your skin adjusts to the medication. If dryness is bothersome, use moisturizer and sunscreen to prevent sunburn.

Safety Advice

Liver disease

Peroclin gel is applied topically with minimal systemic absorption, so liver disease generally does not affect its use. However, patients with severe liver impairment should inform their physician, as higher systemic absorption of clindamycin could potentially occur through damaged skin.

Kidney impairment

Patients with kidney disease do not require specific dosage adjustments when using Peroclin gel—the topical application results in minimal systemic absorption. However, inform your healthcare provider about any kidney conditions before starting treatment.

Pregnant and breastfeeding women

Peroclin gel should be used during pregnancy only if needed. Limited data exist on topical benzoyl peroxide and clindamycin safety during pregnancy. Clindamycin may pass into breast milk when taken orally, but the risk is likely lower with topical application. Consult your healthcare provider regarding risks and benefits if pregnant or breastfeeding.

Avoid

Avoid using Peroclin gel concurrently with products containing retinoids, alpha hydroxy acids, or other potentially irritating ingredients, as this may increase skin irritation. Limit sun exposure and use sunscreen (SPF 30+) while using this medication. Avoid contact with colored fabrics, as benzoyl peroxide has bleaching properties that can discolor clothing, towels, and bedding.