Alphatram 400 Mg/80 Mg Tablet
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What is Alphatram 400/80 Tablet
Alphatram 400/80 is an antibiotic combination medication used to treat various bacterial infections in adults and children. Its primary ingredients are Sulfamethoxazole (400mg) and Trimethoprim (80mg), which belong to the class of antifolate antimicrobials.
This combination works synergistically to combat infections more effectively than either component alone. Alphatram is commonly prescribed for infections of the urinary tract, respiratory tract, and skin and soft tissue.
It's particularly effective against a wide range of gram-positive and gram-negative bacteria. The medication helps alleviate infection symptoms while eliminating the underlying bacterial cause.
Alpha Pharmaceuticals is the leading manufacturer of Alphatram 400/80, ensuring consistent quality and efficacy through rigorous quality control measures. This medication requires a prescription and should only be used under medical supervision to prevent antimicrobial resistance.
What are the benefits of Alphatram 400/80 Tablet
Alphatram 400/80 works through a dual mechanism of action that targets bacterial metabolism. Sulfamethoxazole inhibits the synthesis of dihydrofolic acid, while Trimethoprim blocks the reduction of dihydrofolic acid to tetrahydrofolic acid.
This sequential blockade of folate synthesis disrupts bacterial DNA formation, effectively stopping bacterial reproduction and growth.
The medication offers several key benefits:
- Treats several bacterial infections, including respiratory, urinary, and skin infections.
- Provides prolonged antimicrobial activity requiring fewer daily doses.
- It is often effective against bacteria resistant to other antibiotics.
- Begins relieving symptoms within 24-48 hours in most patients.
It is crucial to note that Alphatram should be taken for the full prescribed course, even if symptoms improve before completion, to prevent bacterial resistance.
How to take Alphatram 400/80 Tablet
Alphatram is a prescription medication that should be taken as per your doctor's instructions.
Here are the general guidelines:
- Take an Alphatram tablet every 12 hours, typically in the morning and evening.
- Swallow the tablet whole with a full glass of water. Do not break or chew.
- It can be taken with or without food, but consistent intake of meals may reduce stomach upset.
- Do not exceed the prescribed dosage of Alphatram tablets.
Strength and substitutes
There are no strength alternatives available for Alphatram. However, the following substitutes are available:
| $0.8/10 Tablets | |
| $2.2/10 Tablets |
What are the side effects of Alphatram 400/80 Tablet
Alphatram is generally well-tolerated when used appropriately. However, it may cause side effects, including:
- Nausea, vomiting, or loss of appetite
- Mild skin rash or itching
- Headache or dizziness
- Photosensitivity (increased sensitivity to sunlight)
- Mild diarrhea or stomach discomfort
These adverse effects do not require medical consultation and disappear as your body adjusts or upon completion of the treatment. However, severe rash, difficulty breathing, or persistent diarrhea should prompt immediate medical attention.
Safety Advice
Liver disease
Patients with liver impairment should use Alphatram with caution. Regular liver function monitoring may be required during treatment. Depending on the severity of liver dysfunction, your doctor may reduce the dosage or increase the interval between doses. Those with severe liver disease may need an alternative antibiotic.
Kidney impairment
Alphatram requires dose adjustment in patients with renal impairment. Creatinine clearance should be monitored before and during treatment. Those with severe kidney disease may need significantly reduced doses or alternative treatment.
Pregnant and breastfeeding women
Alphatram is generally not recommended during pregnancy, as it may cause Kernicterus in the newborn. It should be used only if clearly needed and when potential benefits outweigh the risks. The medicine passes into breast milk and can affect the nursing infant, so alternative feeding methods should be considered during treatment.
Avoid
Avoid consuming alcoholic beverages while taking Alphatram, as it may increase the risk of side effects. Do not take folic acid supplements without medical advice, as they may interfere with the medication's effectiveness.
FAQs
Are there any specific conditions where Alphatram 400/80 should not be used?
Alphatram is contraindicated in patients with known hypersensitivity to Sulfonamides or Trimethoprim, Megaloblastic Anemia due to Folate deficiency, severe liver damage, or Porphyria. It should also be avoided in infants under two months of age and pregnant women near term.
Can Alphatram 400/80 be used for viral infections?
No, Alphatram is only effective against bacterial infections and has no activity against viruses. Using antibiotics for viral infections like common colds or flu is ineffective, contributes to antibiotic resistance, and exposes patients to unnecessary side effects.
How long does it typically take for Alphatram 400/80 to work?
Most people notice symptom improvement within 24-48 hours of starting treatment. However, the complete course (usually 7-14 days, depending on the infection) must be completed to ensure all bacteria are eliminated and prevent recurrence or resistance.
Can I take Alphatram 400/80 with other medications?
Some medications, including blood thinners, certain diabetes medications, and some seizure medications, may interact with Alphatram. Always inform your doctor about your medications to avoid potentially dangerous interactions.
What should I do if I miss a dose of Alphatram 400/80?
Take the missed dose of Alphatram as soon as you remember. If it's close to the time for the next dose, leave the missed one and continue with your regular schedule. Never double dose to make up for a missed one.