Centri 400 mg/80 mg Tablet

What is Centri 400/80 Tablet

Centri 400/80 is a combination antibiotic medication containing Sulfamethoxazole 400mg and Trimethoprim 80mg, commonly referred to as Co-trimoxazole. This dual-action antibiotic effectively treats various bacterial infections, including Urinary Tract Infections (UTIs) and respiratory tract infections such as bronchitis, ear infections, and throat infections.

It works by inhibiting two consecutive steps in bacterial folate synthesis, which is essential for bacterial DNA production and cellular reproduction. Centri 400/80 prevents bacteria from growing and multiplying by targeting this pathway. Centurion Remedies Pvt Ltd is the leading manufacturer of Centri 400/80.

This prescription medication should be used only under medical supervision, as improper use may contribute to antibiotic resistance. The tablets' side effects are generally mild but may include skin rashes, gastrointestinal disturbances, and, rarely, blood disorders. Centri is particularly effective against many gram-positive and gram-negative bacteria that cause common infections.

What are the benefits of Centri 400/80 Tablet

Centri 400/80 delivers powerful antibacterial action through its unique dual-mechanism approach. Combining Sulfamethoxazole and Trimethoprim works synergistically by blocking two bacterial folate synthesis pathway stages. This double action makes the medication more effective than either component used alone and helps prevent the development of bacterial resistance.

Centri 400/80 is effective in treating multiple types of infections:

• Complicated and recurrent cases of UTIs
• Respiratory tract infections, particularly Acute Bronchitis
• Ear infections (Otitis Media)
• Throat infections, including Streptococcal Pharyngitis
• Certain types of Pneumonia, including Pneumocystis Pneumonia

It is important to note that this medication is ineffective against viral infections and should only be used for bacterial infections as a healthcare professional prescribes.

How to take Centri 400/80 Tablet

Centri is a prescription medication that should be taken as per your doctor's instructions. Here are the general guidelines:

• Take Centri tablet twice daily (every 12 hours) unless otherwise directed.
• Take it with a full glass of water without chewing or breaking.
• It is recommended to take this medication with food.
• Do not exceed the prescribed frequency or dosage.

Strength and substitutes

There are no strength alternatives available for Centri. However, the following substitutes are available:

View all substitutes

What are the side effects of Centri 400/80 Tablet

Centri is generally well-tolerated. However, it may cause side effects, including:

• Nausea and vomiting
• Diarrhea or abdominal pain
• Loss of appetite
• Skin rash or itching
• Headache

These adverse effects do not require medical consultation and disappear as your body adjusts to the medication. However, consult your doctor immediately if you experience severe skin reactions, unusual bleeding, or difficulty breathing.

Safety Advice

Liver disease

Patients with liver impairment should use Centri Tablets with caution. The medication is partially metabolized in the liver, and liver disease may lead to increased blood levels and potential toxicity. Dose adjustments may be necessary, and liver function tests should be monitored regularly during treatment, especially for extended therapy.

Kidney impairment

Centri Tablet is primarily excreted by the kidneys, making dose adjustments necessary for patients with kidney impairment. Regular kidney function monitoring and drug levels may be required during treatment.

Pregnant and breastfeeding women

Centri Tablet is generally not recommended during pregnancy, especially during the first and third trimesters. It may interfere with folic acid metabolism and increase the risk of birth defects. It is safe if prescribed during breastfeeding. However, consulting a doctor is necessary.

Avoid

Alcohol consumption should be avoided while taking Centri Tablets as it may increase the risk of side effects.