Centri 400 mg/80 mg Tablet
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CMS7068
What is Centri 400/80 Tablet
Centri 400/80 is a combination antibiotic medication containing Sulfamethoxazole 400mg and Trimethoprim 80mg, commonly referred to as Co-trimoxazole. This dual-action antibiotic effectively treats various bacterial infections, including Urinary Tract Infections (UTIs) and respiratory tract infections such as bronchitis, ear infections, and throat infections.
It works by inhibiting two consecutive steps in bacterial folate synthesis, which is essential for bacterial DNA production and cellular reproduction. Centri 400/80 prevents bacteria from growing and multiplying by targeting this pathway. Centurion Remedies Pvt Ltd is the leading manufacturer of Centri 400/80.
This prescription medication should be used only under medical supervision, as improper use may contribute to antibiotic resistance. The tablets' side effects are generally mild but may include skin rashes, gastrointestinal disturbances, and, rarely, blood disorders. Centri is particularly effective against many gram-positive and gram-negative bacteria that cause common infections.
What are the benefits of Centri 400/80 Tablet
Centri 400/80 delivers powerful antibacterial action through its unique dual-mechanism approach. Combining Sulfamethoxazole and Trimethoprim works synergistically by blocking two bacterial folate synthesis pathway stages. This double action makes the medication more effective than either component used alone and helps prevent the development of bacterial resistance.
Centri 400/80 is effective in treating multiple types of infections:
- Complicated and recurrent cases of UTIs
- Respiratory tract infections, particularly Acute Bronchitis
- Ear infections (Otitis Media)
- Throat infections, including Streptococcal Pharyngitis
- Certain types of Pneumonia, including Pneumocystis Pneumonia
It is important to note that this medication is ineffective against viral infections and should only be used for bacterial infections as a healthcare professional prescribes.
How to take Centri 400/80 Tablet
Centri is a prescription medication that should be taken as per your doctor's instructions. Here are the general guidelines:
- Take Centri tablet twice daily (every 12 hours) unless otherwise directed.
- Take it with a full glass of water without chewing or breaking.
- It is recommended to take this medication with food.
- Do not exceed the prescribed frequency or dosage.
Strength and substitutes
There are no strength alternatives available for Centri. However, the following substitutes are available:
| $0.8/10 Tablets | |
| $2.2/10 Tabletsx |
What are the side effects of Centri 400/80 Tablet
Centri is generally well-tolerated. However, it may cause side effects, including:
- Nausea and vomiting
- Diarrhea or abdominal pain
- Loss of appetite
- Skin rash or itching
- Headache
These adverse effects do not require medical consultation and disappear as your body adjusts to the medication. However, consult your doctor immediately if you experience severe skin reactions, unusual bleeding, or difficulty breathing.
Safety Advice
Liver disease
Patients with liver impairment should use Centri Tablets with caution. The medication is partially metabolized in the liver, and liver disease may lead to increased blood levels and potential toxicity. Dose adjustments may be necessary, and liver function tests should be monitored regularly during treatment, especially for extended therapy.
Kidney impairment
Centri Tablet is primarily excreted by the kidneys, making dose adjustments necessary for patients with kidney impairment. Regular kidney function monitoring and drug levels may be required during treatment.
Pregnant and breastfeeding women
Centri Tablet is generally not recommended during pregnancy, especially during the first and third trimesters. It may interfere with folic acid metabolism and increase the risk of birth defects. It is safe if prescribed during breastfeeding. However, consulting a doctor is necessary.
Avoid
Alcohol consumption should be avoided while taking Centri Tablets as it may increase the risk of side effects.
FAQs
Can the use of Centri 400mg/80mg Tablet cause nausea and vomiting?
Yes, nausea and vomiting are common side effects of Centri 400/80. Taking the medication with food may help reduce these symptoms. If severe or persistent, consult your healthcare provider as dose adjustment or alternative antibiotics might be necessary.
Are there any specific contraindications associated with the use of Centri 400mg/80mg Tablet?
Centri 400/80 is contraindicated in patients with known hypersensitivity to sulfonamides or trimethoprim, severe liver disease, blood disorders, porphyria, and G6PD deficiency. It should not be used in infants under 2 months or during late pregnancy and breastfeeding.
Can I stop taking Centri 400mg/80mg Tablet when my symptoms are relieved?
No, you should complete the full prescribed course of Centri 400/80, even if symptoms improve before completion. Stopping early may lead to incomplete eradication of bacteria, increasing the risk of infection recurrence and antibiotic resistance development.
What if I don't get better after using Centri 400mg/80mg Tablet?
If your symptoms don't improve after 2-3 days of treatment with Centri 400/80, or if they worsen at any time, contact your healthcare provider immediately. This could indicate bacterial resistance, incorrect diagnosis, or a need for additional or alternative treatment.
How much water should I drink while taking Centri 400mg/80mg Tablet?
It's important to drink plenty of water while taking Centri Tablets, at least 1.5-2 liters daily, to prevent crystal formation in the urine and potential kidney problems. Adequate hydration also helps reduce the risk of side effects and improves the medication's effectiveness.