Citafine 1400 Mg Injection

What is Citafine 1400 Mg

Citafine 1400 mg is a chemotherapeutic agent used to treat various types of cancer in adult patients. Its primary ingredient is Gemcitabine, which is a nucleoside analog antimetabolite. Gemcitabine works by interfering with cancer cell DNA replication and repair, ultimately leading to cancer cell death.

It is primarily indicated for pancreatic cancer, non-small cell lung cancer, bladder cancer, and breast cancer, either as monotherapy or in combination with other anticancer agents. Emcure Pharmaceuticals Ltd is the leading manufacturer of Citafine 1400 mg.

This medication requires careful administration by healthcare professionals in clinical settings with appropriate monitoring for potential adverse effects, including myelosuppression, pulmonary toxicity, and renal impairment.

What are the benefits of Citafine 1400 mg

Citafine 1400 mg delivers Gemcitabine, which acts by incorporating itself into DNA during cellular replication. Once inside the DNA, it prevents further DNA synthesis and triggers apoptosis (programmed cell death) in rapidly dividing cancer cells. This mechanism makes it particularly effective at disrupting the abnormal growth cycles of cancer cells while allowing normal cells some recovery time between treatments.

Citafine is used for treating multiple types of cancer:

• Pancreatic cancer (both metastatic and locally advanced cases).
• Non-small cell lung cancer (as first-line combination treatment).
• Bladder cancer (particularly advanced or metastatic transitional cell carcinoma).
• Breast cancer (as part of combination therapy protocols).
• Ovarian cancer

It is crucial to note that Citafine must be administered under direct medical supervision with regular monitoring of blood counts and organ function.

How to take Citafine 1400 mg

Citafine is a prescription medication that should be administered only by qualified healthcare professionals. Here are the general guidelines:

• Citafine 1400 injection is typically administered as an intravenous infusion over 30 minutes.
• The standard dosing schedule varies by cancer type, generally following weekly protocols.
• Premedication with antiemetics is recommended to prevent nausea and vomiting.
• Do not exceed manufacturer-recommended dosing intervals to prevent cumulative toxicity.

Strength and substitutes

Cheap Medicine Shop provides other strengths for Citafine:

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What are the side effects of Citafine 1400 mg

Citafine can cause significant side effects that require monitoring. Common side effects include:

• Nausea and vomiting
• Flu-like symptoms (fever, headache, fatigue)
• Peripheral edema (swelling)
• Rash or skin reactions

These adverse effects usually resolve quickly. However, if they persist, they may require medical supervision and necessitate dose adjustments or supportive care measures.

Safety Advice

Liver disease

Patients with liver impairment should be treated with caution. Regular monitoring of liver function tests is essential before and during treatment. Treatment should be discontinued if liver toxicity progresses.

Kidney impairment

Regular assessment of renal function is recommended throughout the treatment course. Consult a doctor for safety.

Pregnant and breastfeeding women

Citafine 1400 is contraindicated during pregnancy as it can cause fetal harm. Women of childbearing potential should use effective contraception during and for 6 months after treatment. Breastfeeding should be discontinued during Citafine treatment and for at least one week following the final dose due to potentially serious adverse reactions in nursing infants.

Avoid

Alcohol should be avoided during treatment as it may exacerbate liver toxicity. Live vaccines should not be administered during treatment due to immunosuppressive effects. Individuals should also avoid grapefruit and grapefruit juice, which may interfere with drug metabolism. Supplements containing St. John's Wort may reduce drug effectiveness and should be discontinued.