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Humalog Mix 50 Kwikpen is a dual-acting Insulin preparation used to treat Type 1 and Type 2 Diabetes Mellitus in adults. Its primary ingredients are 50% Insulin Lispro (a rapid-acting Insulin analog) and 50% Insulin Lispro Protamine suspension (an intermediate-acting Insulin), providing immediate and extended blood glucose control.
This pre-filled disposable pen delivers precisely measured doses without needing separate vials and syringes. Side effects of Humalog may include Hypoglycemia, injection site reactions, lipodystrophy, and allergic responses.
Humalog Mix 50 Kwikpen should be stored in a refrigerator (2°C-8°C) before first use and can be kept at room temperature (below 30°C) for up to 10 days after opening. Eli Lilly is the renowned manufacturer of Humalog Mix 50 Kwikpen. The medication should never be frozen and must be protected from direct heat and light to maintain potency.
Humalog Mix 50 Kwikpen combines the rapid action of Insulin Lispro with the sustained effect of Insulin Lispro Protamine in a convenient 50:50 ratio. The Insulin Lispro component works within 15 minutes to control post-meal glucose spikes, while the Protamine component provides steady Insulin coverage for 12-16 hours.
This unique formulation offers multiple advantages:
It is crucial to note that the timing of administration, typically 15 minutes before meals, is important to match the Insulin action profile with food absorption.
Humalog Mix Kwikpen is a prescription medication that should be taken as per your doctor's instructions. Here are the general guidelines:
The strengths and substitutes available for Humalog Mix 50 KwikPen are:
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Humalog Mix 50 Kwikpen is generally well-tolerated when used correctly. However, it may cause side effects, including:
These adverse effects can typically be managed with proper technique, site rotation, and blood glucose monitoring. However, Hypoglycemia requires immediate attention when consumed with glucose or sugary foods.
Liver disease
Patients with liver impairment may have reduced Insulin requirements due to decreased capacity for gluconeogenesis and Insulin metabolism. More frequent blood glucose monitoring is recommended in these patients. Dose reductions may be necessary and should be determined by the doctor.
Kidney impairment
Insulin clearance can be reduced in patients with kidney disease, potentially lowering Insulin requirements. Careful blood glucose monitoring is essential, and dosage adjustments may be needed. Those with severe renal impairment should be closely monitored for Hypoglycemia and may require significant dose modifications.
Pregnant and breastfeeding women
Humalog Mix 50 may be used during pregnancy and breastfeeding when clinically indicated. Insulin requirements typically fluctuate during pregnancy, often decreasing in the first trimester and increasing in the second and third trimesters. Close monitoring of blood glucose and regular consultation with medical experts are essential to adjust the dosage appropriately.
Avoid
Alcohol may increase the risk of Hypoglycemia by enhancing Insulin's glucose-lowering effect and impairing the liver's ability to release glucose. Certain medications, like beta-blockers, MAO inhibitors, and salicylates, might also affect blood glucose levels and Insulin requirements.
Humalog Mix 50 contains equal parts (50:50) of rapid-acting and intermediate-acting Insulin, whereas other mixtures may have different ratios. This balanced formulation is designed for patients who need more rapid-acting Insulin coverage with meals.
Before each use, perform a safety test by dialing 2 units and pressing the injection button while holding the pen upright. You should see Insulin at the needle tip. If not, repeat the test before injecting.
No, Humalog Mix 50 should not be mixed with other Insulin preparations. It is already a premixed formulation, and adding other Insulins would alter its carefully balanced action profile. If you have concerns, consult a doctor.
Consume 15-20 grams of fast-acting carbohydrates, like glucose tablets, fruit juice, or regular soda. Check your blood glucose after 15 minutes and repeat treatment if it is still low. Follow with a meal or snack containing complex carbohydrates. Always discuss safety concerns with the doctor.
Once in use, the Humalog Mix 50 Kwikpen can be stored at room temperature (below 30°C) for up to 10 days. Discard the pen after this period, even if it still contains Insulin.
