Nobegliz 60 XR Tablet
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CMS8446
What is Nobegliz 60 XR
Nobegliz 60 XR is an extended-release antidiabetic medication containing Gliclazide (60 mg) as its active ingredient. This medicine belongs to the sulfonylurea class. It is specifically formulated to provide sustained glucose control throughout the day for patients with Type 2 Diabetes Mellitus.
Mankind Pharma Ltd is the manufacturer of Nobegliz XR. The extended-release formulation ensures consistent blood sugar management with once-daily dosing convenience.
Gliclazide is a sulfonylurea medicine that stimulates Insulin release from pancreatic beta cells. This mechanism helps effectively reduce elevated blood glucose levels in diabetic patients.
Common side effects include Hypoglycemia, weight gain, nausea, and gastrointestinal disturbances. The medicine should be stored at room temperature. Keep it away from moisture and heat.
Patients with liver or kidney impairment require careful monitoring and possible dose adjustments. Regular blood glucose monitoring is essential to prevent Hypoglycemic episodes and optimize therapeutic outcomes.
What are the benefits of Nobegliz 60 XR
Nobegliz 60 XR delivers sustained glycemic control through its innovative extended-release technology. Gliclazide stimulates pancreatic beta cells to increase Insulin secretion in a glucose-dependent manner.
This glucose-dependent action supports more natural insulin release in response to meals, helping to smooth postprandial glucose levels. The extended-release formulation provides several advantages for Diabetes management.
It offers 24-hour glucose control with convenient once-daily dosing, significantly improving patient compliance. The medication demonstrates excellent efficacy in reducing HbA1c levels and fasting plasma glucose concentrations.
According to some studies, Gliclazide helps preserve pancreatic beta cell function through its protective effects. The sustained-release technology minimizes the risk of Hypoglycemic episodes compared to immediate-release formulations.
It is crucial to note that this medication works best when combined with proper diet and regular exercise regimens.
How to take Nobegliz 60 XR
Nobegliz XR is a prescription medication that should be taken as per your doctor's instructions. Here are the general guidelines:
- Take Nobegliz 60 XR once daily with breakfast or the first main meal.
- Swallow the tablet without crushing, chewing, or breaking the extended-release coating.
- Maintain consistent timing daily. Take it with food and never skip meals to prevent Hypoglycemia.
- Do not exceed 1 tablet daily unless specifically advised by your healthcare provider.
Strengths and substitutes
The strengths and substitutes available at Cheap Medicine Shop are:
| Glizid 40 mg | $1.30/10 tablets |
| Glizid 80 mg | $2.10/10 tablets |
What are the side effects of Nobegliz 60 XR
Nobegliz XR is generally safe when used under medical supervision. However, it may cause side effects, including:
- Hypoglycemia with symptoms like sweating, trembling, and dizziness
- Weight gain due to improved glucose utilization and increased appetite
- Nausea
- Vomiting
- Abdominal discomfort
- Skin rashes
- Allergic reactions in sensitive individuals
These adverse effects typically resolve with continued use and proper dose adjustment under medical guidance. If they persist, seek medical advice immediately.
Safety Advice
Liver disease
Patients with hepatic impairment should use Nobegliz XR cautiously, as liver dysfunction may prolong drug elimination. Regular liver function monitoring is recommended during treatment. Dose reduction might be necessary in moderate to severe liver disease. Avoid use in people with severe hepatic dysfunction. Always confirm with a doctor before use.
Kidney impairment
Nobegliz XR requires dose adjustment in patients with kidney disease, as reduced clearance increases the risk of Hypoglycemia. Regular monitoring of kidney function through serum creatinine and eGFR is essential. Elderly patients need special attention due to age-related kidney function decline and increased sensitivity to Hypoglycemic effects. Always confirm with a doctor before use.
Pregnant and breastfeeding women
Nobegliz XR is not recommended during pregnancy, as it may cause neonatal Hypoglycemia and birth complications as per limited available data. Insulin therapy is the preferred treatment for gestational Diabetes. The medication might pass into breast milk, potentially causing Hypoglycemia in nursing infants. Consult your healthcare provider for safe alternatives during breastfeeding.
Avoid
Avoid alcohol use as it increases the risk of Hypoglycemia and may cause severe reactions. Skip grapefruit and grapefruit juice as they may enhance drug effects unpredictably. Avoid skipping meals or prolonged fasting periods to prevent dangerous blood sugar drops. Do not combine with certain antibiotics and antifungal medications without medical supervision.
FAQs
What time of day should I take Nobegliz 60 XR?
Take a Nobegliz XR tablet with breakfast or your first substantial meal of the day. This timing helps optimize glucose control and reduces Hypoglycemia risk throughout the day. However, it is best to follow your doctor's advice.
Can Nobegliz 60 XR cause low blood sugar?
Yes, Hypoglycemia is a possible side effect of Nobegliz XR tablets, especially if you skip meals, exercise excessively, or consume alcohol. Always carry glucose tablets and maintain regular meal schedules.
How quickly does Nobegliz 60 XR start working?
Blood glucose reduction typically begins within 2-4 hours of taking the medication. Maximum effects are achieved within 6-8 hours and sustained for 24 hours with the extended-release formulation. However, effects vary for each individual.
Is it safe to drive while taking Nobegliz 60 XR?
Exercise caution when driving, especially during the initial weeks of using this tablet. Hypoglycemic episodes can impair concentration and reaction times. Monitor blood sugar levels regularly and avoid driving during low glucose episodes.
Can I split or crush Nobegliz 60 XR tablets?
No, you should never split, crush, or chew Nobegliz 60 XR tablets, as this destroys the extended-release mechanism. Swallow tablets whole with water to ensure proper sustained release and effectiveness. It is best taken with a meal.